Korany A Ali, Mokhles M Abd-Elzaher, Khaled Mahmoud
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引用次数: 28
摘要
合成了几种新的2,6-二(取代)吡啶配体和2,6-二(取代)吡啶银(I)硝酸配合物，并对其进行了光谱表征。新合成的配体包括吡啶-2,6-二(3-氧丙烯腈)(1)、吡啶-2,6-二(2-氰基- n -苯基-3-氧丙烯乙酰胺)(2)和吡啶-2,6-二((E)-2-(2-苯腙)-3-氧丙烯腈)(3)。研究了新合成的配体和银(I)配合物对肝癌(HePG2)、肺腺癌(A549)、结肠癌(HT29)和乳腺腺癌(MCF7)等4种人类癌细胞的体外抗癌活性。大多数新合成的银(I)配合物表现出比配体更好的活性，并将结果与阿霉素作为对照药物进行了比较。
Synthesis and Anticancer Properties of Silver(I) Complexes Containing 2,6-Bis(substituted)pyridine Derivatives.
Several new 2,6-bis(substituted)pyridine ligands and 2,6-bis(substituted)pyridine Ag(I) nitrate complexes were synthesized and characterized spectroscopically. The newly synthesized ligands include pyridine-2,6-bis(3-oxopropanenitrile) (1), pyridine-2,6-bis(2-cyano-N-phenyl-3-oxopropanethioamide) (2), and pyridine-2,6-bis((E)-2-(2-phenylhydrazono)-3-oxopropanenitrile) (3). The newly synthesized ligands and silver(I) complexes were evaluated for their in vitro anticancer activity against four human cancer cell lines including hepatocellular carcinoma (HePG2), lung adenocarcinoma (A549), colon carcinoma (HT29), and breast adenocarcinoma (MCF7). Most of the newly synthesized silver(I) complexes exhibited better activity than the ligands, and the results have been compared with doxorubicin as a reference drug.
期刊介绍：
International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis. International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis.
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