新型抗菌剂:氟化2-(3-(苯并呋喃-2-基)吡唑-1-基)噻唑。

International Journal of Medicinal Chemistry Pub Date : 2013-01-01 Epub Date: 2013-09-11 DOI:10.1155/2013/986536

Hanan A Mohamed, Ehab Abdel-Latif, Bakr F Abdel-Wahab, Ghada E A Awad

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引用次数: 8

摘要

以n-硫代氨基-2-吡唑啉为原料，与不同的卤酮和2,3-二氯喹啉环化，合成了一系列新的2-吡唑啉-1-基噻唑8a-d和13-16。新化合物的结构通过元素分析以及核磁共振、红外和质谱数据得到证实。对新合成的化合物进行了抑菌活性评价，并测定了它们对大多数受试生物的最低抑菌浓度(MIC)。其中化合物8c表现出良好的抑菌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles.

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Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles.

A new series of 2-pyrazolin-1-ylthiazoles 8a-d and 13-16 was synthesized by cyclization of N-thiocarboxamide-2-pyrazoline with different haloketones and 2,3-dichloroquinoxaline. The structures of the new compounds were confirmed by elemental analyses as well as NMR, IR, and mass spectral data. The newly synthesized compounds were evaluated for their antimicrobial activities, and also their minimum inhibitory concentration (MIC) against most of test organisms was performed. Amongst the tested ones, compound 8c displayed excellent antimicrobial activity.

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来源期刊

International Journal of Medicinal Chemistry CHEMISTRY, MEDICINAL-

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期刊介绍： International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis. International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis.