一些新的功能化三苯基衍生物的合成、表征及生物学评价。

International Journal of Medicinal Chemistry Pub Date : 2012-01-01 Epub Date: 2012-12-13 DOI:10.1155/2012/530392

Seranthimata Samshuddin, Badiadka Narayana, Balladka Kunhanna Sarojini, Divya N Shetty, Nalilu Suchetha Kumari

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引用次数: 13

摘要

以4,4'-二氟查尔酮为主要中间体，以4,4'-二氟-5'-羟基-1,1':3'，1' -terphenyl-4'- carbohydraide为主要中间体，制备了含有多种杂环的新型功能化terphenyl衍生物。所有衍生物都通过(1)H NMR, IR和质谱数据进行了表征。所有合成产物都进行了体外抗菌和抗氧化性能的筛选。大部分化合物具有显著的抗氧化活性，部分化合物具有良好的抗菌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis, characterization, and biological evaluation of some new functionalized terphenyl derivatives.

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Synthesis, characterization, and biological evaluation of some new functionalized terphenyl derivatives.

New functionalized terphenyl derivatives incorporating various heterocyclic rings are prepared by using 4,4''-difluoro-5'-hydroxy-1,1':3',1''-terphenyl-4'-carbohydrazide as a key intermediate derived from 4,4'-difluoro chalcone, a versatile synthone. All the derivatives are characterized by (1)H NMR, IR, and mass spectral data. All the synthesized products are screened for their in vitro antimicrobial and antioxidant properties. The majority of the tested compounds exhibited significant antioxidant activity and some of them showed good antimicrobial activity.

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来源期刊

International Journal of Medicinal Chemistry CHEMISTRY, MEDICINAL-

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期刊介绍： International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis. International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis.