腹膜透析患者水合和营养状况对沃森配方的影响。

Masahide Furusho, Junxiong Weng, Takefumi Mori, Tao Wang
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引用次数: 0

摘要

尿素清除率(Kt/V尿素),使用Watson公式(TBW(Watson))根据全身水分(TBW)进行调整,被广泛用于指导腹膜透析(PD)处方并确保透析充分性。体成分对TBW(Watson)测定的影响已经确定,但水化和营养状况对TBW(Watson)的影响尚不清楚。因此,我们研究了水合和营养状况对PD患者TBW(Watson)的影响。本研究纳入195名PD患者和33名健康对照。采用多频生物电阻抗谱法(MF-BIS)测量TBW,并与TBW(Watson)进行比较。根据患者的过水化程度[δ水化状态(OH),单位为升]将患者分为正常水化组(OH: < 2.0 L)、轻度水化组(OH: 2.0 - 4.0 L)和严重水化组(OH: > 4.0 L)。与df - bis相比,Watson公式高估了正常水化患者的TBW,低估了严重水化患者的TBW。此外,在水分正常的患者中,22例主观整体评估为营养不良,TBW(Watson)高估值明显高于营养良好的患者。我们的研究表明,水合作用和营养状况都对PD患者的TBW(Watson)有很大影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of hydration and nutrition status on the Watson formula in peritoneal dialysis patients.

Urea clearance (Kt/V urea), adjusted for total body water (TBW) using the Watson formula (TBW(Watson)), is widely used to guide peritoneal dialysis (PD) prescription and to ensure dialysis adequacy. The impact of body composition on the determination of TBW(Watson) is well established, but the effect of hydration and nutrition status on TBW(Watson) is not understood. We therefore studied the effects of hydration and nutrition status on TBW(Watson) in PD patients. Our study enrolled 195 PD patients and 33 healthy control subjects. Multiple-frequency bioelectrical impedance spectroscopy (MF-BIS) was used to measure TBW and the result was compared with TBW(Watson). Patients were divided into three groups according to their degree of overhydration [deltahydration status (OH) in liters]: normally hydrated group (OH: < 2.0 L), mildly overhydrated group (OH: 2.0 - 4.0 L), and severely overhydrated group (OH: > 4.0 L). Compared with MF-BIS, the Watson formula overestimated TBW in normally hydrated patients, but underestimated TBW in severely overhydrated patients. In addition, of the normally hydrated patients, 22 were malnourished by subjective global assessment, and the TBW(Watson) overestimation was much greater in them than in the well-nourished patients. Our study suggests that hydration and nutrition status both strongly affect TBW(Watson) in PD patients.

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