蛋白质乙酰化与精子发生。

Aly Pang, Om Rennert
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引用次数: 17

摘要

精子发生是指从原精子干细胞到成熟精子形成雄性生殖细胞的发育过程。男性生殖细胞在不同发育阶段的进展,以及细胞大小和形态的变化,涉及其基因表达程序在转录物和蛋白质水平上的协调变化。众所周知,蛋白质的稳定性、生物活性和细胞定位受翻译后修饰的调控。在这篇综述中,我们简要介绍了目前关于蛋白质乙酰化在哺乳动物精子发生中的作用的最新知识。根据最近的发现,具体的例子被引用来说明这些修饰是如何参与控制对男性生殖细胞正常发育重要的不同事件的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protein acetylation and spermatogenesis.

Spermatogenesis refers to the developmental process of male germ cell formation from the spermatogonial stem cell to mature spermatozoa. The progression of male germ cells through the different phases of development, along with changes in cellular size and morphology, involves a coordinated change in their gene expression program at both the transcript and protein levels. It is well known that the stability, biological activity and cellular localization of proteins are regulated by post-translational modifications. In this review, we provide a brief update of current knowledge about the role of protein acetylation in mammalian spermatogenesis. Based on recent findings specific examples were cited to illustrate how these modifications are involved in controlling the different events that are important to the proper development of male germ cells.

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