eb病毒感染机制。

Q Medicine

癌症 Pub Date : 2014-11-01 Epub Date: 2014-10-17 DOI:10.5732/cjc.014.10168

Liudmila S Chesnokova, Lindsey M Hutt-Fletcher

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引用次数: 28

摘要

eb病毒(EBV)感染通过不同细胞类型的不同机制发生。eb病毒在体外感染B细胞最少需要5种病毒糖蛋白和2种细胞蛋白。相比之下，上皮细胞的感染至少需要3种病毒糖蛋白，它们能够与3种不同的细胞蛋白中的一种或多种相互作用。进入体内能够被感染的所有细胞类型所涉及的全部蛋白质补体是未知的。这篇综述讨论了当病毒进入细胞细胞质时发生的事件，已知参与这些事件的参与者，以及这些参与者被认为是如何起作用的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Epstein-Barr virus infection mechanisms.

Epstein-Barr virus (EBV) infection occurs by distinct mechanisms across different cell types. EBV infection of B cells in vitro minimally requires 5 viral glycoproteins and 2 cellular proteins. By contrast, infection of epithelial cells requires a minimum of 3 viral glycoproteins, which are capable of interacting with one or more of 3 different cellular proteins. The full complement of proteins involved in entry into all cell types capable of being infected in vivo is unknown. This review discusses the events that occur when the virus is delivered into the cytoplasm of a cell, the players known to be involved in these events, and the ways in which these players are thought to function.

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来源期刊

癌症 ONCOLOGY-

CiteScore

3.47

自引率

0.00%

发文量

9010

审稿时长

12 weeks

期刊介绍： In July 2008, Landes Bioscience and Sun Yat-sen University Cancer Center began co-publishing the international, English-language version of AI ZHENG or the Chinese Journal of Cancer (CJC). CJC publishes original research, reviews, extra views, perspectives, supplements, and spotlights in all areas of cancer research. The primary criteria for publication in CJC are originality, outstanding scientific merit, and general interest. The Editorial Board is composed of members from around the world, who will strive to maintain the highest standards for excellence in order to generate a valuable resource for an international readership.