脑源性神经营养因子在精神障碍中的自杀作用。

IF 2.6 4区 医学 Q3 NEUROSCIENCES
Acta Neuropsychiatrica Pub Date : 2014-12-01 Epub Date: 2014-10-13 DOI:10.1017/neu.2014.27
Majda Grah, Mate Mihanovic, Nedjeljka Ruljancic, Branka Restek-Petrovic, Sven Molnar, Silvana Jelavic
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引用次数: 32

摘要

目的:脑源性神经营养因子(brain -derived neurotrophic factor, BDNF)在脑可塑性过程中起着至关重要的作用,其血清水平在包括自杀行为在内的不同精神障碍患者中发生改变。本研究的目的是检查血清BDNF水平之间的关系,作为抑郁症,人格障碍(pd)和适应障碍(ADs)患者自杀行为的可能外围指标,有或没有自杀企图。方法:随机选取172例复发性抑郁障碍(RDD;F 33.2),情绪不稳定的PD (F 60.3)和AD (F 43.2),根据ICD-10(国际疾病与相关健康问题统计分类第10版)的标准有或没有自杀未遂,60名表型健康对照受试者。在这组患者中,73%的受试者接受了某种形式的精神药物治疗。采用酶联免疫吸附法测定血清BDNF水平。结果:PD和AD患者有自杀企图者血清BDNF水平明显低于无自杀企图者。在PD和AD患者组中,接受精神药物治疗的患者血清BDNF水平较高。在RDD患者组中,在自杀企图或精神药物治疗方面没有差异。逻辑回归分析表明,精神药物治疗和血清BDNF水平与自杀企图有统计学相关性。结论:PD和AD患者自杀未遂者血清BDNF水平较低,提示血清BDNF水平是自杀行为的潜在标志,独立于精神障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Brain-derived neurotrophic factor as a suicide factor in mental disorders.

Objective: Brain-derived neurotrophic factor (BDNF) plays a critical role in brain plasticity processes and serum levels have been demonstrated to be altered in patients with different mental disorder including suicidal behaviour. The objective of this study was to examine the association between serum BDNF levels as a possible peripheral indicator of suicide behaviour in subjects suffering from depression, personality disorders (PDs) and adjustment disorders (ADs) with or without suicide attempt.

Methods: The research included 172 randomly selected individuals suffering from recurrent depressive disorder (RDD; F 33.2), emotionally unstable PD (F 60.3) and AD (F 43.2), with or without attempted suicide according to the criteria of the ICD-10 (International Statistical Classification of Diseases and Related Health Problems 10th Revision) and 60 phenotypically health control subjects. In the group of patients, 73% subjects took some form of psychopharmacotherapy. Serum BDNF levels were measured by enzyme linked immunosorbent assay.

Results: Subjects with PD and AD with suicide attempts had significantly lower serum BDNF levels than those without suicide attempts. In groups of subjects with PD and AD, those taking psychopharmacotherapy had higher serum BDNF levels. In the group of subjects with RDD, there were no differences with respect to suicide attempts or psychopharmacotherapy. Logistical regression analysis was indicated that psychopharmacotherapy and serum BDNF levels statistically correlated with suicide attempts.

Conclusion: The lower levels of BDNF in subjects suffering from PD and AD with suicide attempts, suggest that the serum BDNF level is a potential marker of suicidal behaviour, independent of mental disorders.

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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY
自引率
5.30%
发文量
30
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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