基底细胞癌光动力治疗六年经验:191个病灶的结果和荧光诊断。

IF 1.2 Q3 DERMATOLOGY
Journal of Skin Cancer Pub Date : 2014-01-01 Epub Date: 2014-09-14 DOI:10.1155/2014/849248
M Fernández-Guarino, A Harto, B Pérez-García, A Royuela, P Jaén
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引用次数: 13

摘要

背景。近十年来,光动力疗法(PDT)已成为基底细胞癌(BCC)的一种治疗选择。目标。目的:研究PDT治疗BCC的结果和预测因素,评价BCC的荧光诊断。方法。进行了一项描述性、回顾性和观察性研究。选择活检证实的BCC患者,根据标准治疗方案(2个疗程,间隔2周,630 nm, 37 J/cm(2), 8分钟,Aktilite)接受甲基氨基乙酰丙酸和红光治疗。疗效分为临床完全和不完全,每3个月随访一次。结果。181例191例BCC患者的数据,平均年龄69.55岁,平均随访时间34.4个月。总体缓解率为接受治疗的BCC的74%,浅表BCC的最佳缓解率为完全缓解的95%。回归分析显示,表面组织学类型是预测完全缓解的主要因素。结论。在用PDT治疗BCC时,预测疗效的最重要因素是组织学类型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Six years of experience in photodynamic therapy for Basal cell carcinoma: results and fluorescence diagnosis from 191 lesions.

Six years of experience in photodynamic therapy for Basal cell carcinoma: results and fluorescence diagnosis from 191 lesions.

Six years of experience in photodynamic therapy for Basal cell carcinoma: results and fluorescence diagnosis from 191 lesions.

Six years of experience in photodynamic therapy for Basal cell carcinoma: results and fluorescence diagnosis from 191 lesions.

Background. Photodynamic therapy (PDT) has become a therapeutic option for basal cell carcinoma (BCC) in the last decade. Objectives. To study the results and predictors of BCC response to treatment with PDT and to evaluate fluorescence diagnosis of BCC. Methods. A descriptive, retrospective, and observational study was carried out. Patients with biopsy-confirmed BCC who were treated with methyl aminolevulinate and red light according to standard treatment protocols (2 sessions separated by 2 weeks, 630 nm, 37 J/cm(2), 8 minutes, Aktilite) were selected. Response was scored as clinically complete and incomplete and the patients were followed up every three months. Results. Data from 191 BCC in 181 patients with a mean age of 69.55 years and a mean follow-up period of 34.4 months were collected. The overall response was 74% of the BCC treated, with the best response in superficial BCC with a 95% of complete response. The regression analysis revealed that the superficial histological type was the primary factor predictive of a complete response. Conclusions. In the treatment of BCC with PDT, the most significant factor for predicting response is the histological type.

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来源期刊
Journal of Skin Cancer
Journal of Skin Cancer DERMATOLOGY-
CiteScore
2.30
自引率
18.20%
发文量
12
审稿时长
21 weeks
期刊介绍: Journal of Skin Cancer is a peer-reviewed, Open Access journal that publishes clinical and translational research on the detection, diagnosis, prevention, and treatment of skin malignancies. The journal encourages the submission of original research articles, review articles, and clinical studies related to pathology, prognostic indicators and biomarkers, novel therapies, as well as drug sensitivity and resistance.
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