性发育障碍患者生殖细胞癌分子标志物研究进展。

Endocrine development Pub Date : 2014-01-01 Epub Date: 2014-09-09 DOI:10.1159/000363641

Yvonne G van der Zwan, Martine Cools, Leendert H J Looijenga

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引用次数: 1

摘要

在性发育障碍患者中，生殖细胞恶性转化导致生殖细胞癌(GCC)的风险是高度异质性的，依赖于许多参数，其中y染色体物质的存在是必不可少的。本章描述了与正常性腺发育和GCC相关的蛋白质编码和调控过程，并重点介绍了早期诊断分子标记的最新进展。

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Advances in molecular markers of germ cell cancer in patients with disorders of sex development.

The risk of malignant transformation of germ cells, leading to germ cell cancer (GCC) in patients with disorders of sex development, is highly heterogeneous and dependent on a number of parameters, of which the presence of Y-chromosomal material is essential. This chapter describes the networks, both protein-coding and regulatory processes, related to normal gonadal development and GCC, with focus on recent advances of molecular markers for early diagnosis.

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Endocrine development

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