GLP-2:我们知道什么?我们会发现什么?

Sara Baldassano, Antonella Amato
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引用次数: 33

摘要

胰高血糖素样肽2 (Glucagon-like peptide 2, GLP-2)是一种由肠粘膜肠内分泌l细胞释放的含有33个氨基酸的肽。GLP-2的作用是由GLP-2受体[GLP-2R]转导的,GLP-2受体定位于肠神经系统的神经元,而不定位于肠上皮,表明其作用机制是间接的。GLP-2因其在肠道内的营养作用而闻名,现在,基于GLP-2R激动剂被批准用于治疗短肠综合征[SBS],对GLP-2的兴趣正在复苏。最近,它似乎也与葡萄糖稳态有关。这篇综述的目的是概述神经内分泌肽,特别是GLP-2在胃肠功能肠调节中的重要性,并重点介绍新的工作,以呈现GLP-2的创新图景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
GLP-2: What do we know? What are we going to discover?

Glucagon-like peptide 2 [GLP-2] is a 33-amino acid peptide released from the mucosal enteroendocrine L-cells of the intestine. The actions of GLP-2 are transduced by the GLP-2 receptor [GLP-2R], which is localized in the neurons of the enteric nervous system but not in the intestinal epithelium, indicating an indirect mechanism of action. GLP-2 is well known for its trophic role within the intestine and interest in GLP-2 is now reviving based on the approval of the GLP-2R agonist for treatment of short bowel syndrome [SBS]. Recently it also seems to be involved in glucose homeostasis.

The aim of this review is to outline the importance of neuroendocrine peptides, specifically of GLP-2 in the enteric modulation of the gastrointestinal function and to focus on new works in order to present an innovative picture of GLP-2.

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来源期刊
Regulatory Peptides
Regulatory Peptides 医学-内分泌学与代谢
自引率
0.00%
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审稿时长
2 months
期刊介绍: Regulatory Peptides provides a medium for the rapid publication of interdisciplinary studies on the physiology and pathology of peptides of the gut, endocrine and nervous systems which regulate cell or tissue function. Articles emphasizing these objectives may be based on either fundamental or clinical observations obtained through the disciplines of morphology, cytochemistry, biochemistry, physiology, pathology, pharmacology or psychology.
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