循环弹性蛋白肽,在血管病理中的作用

L. Robert, J. Labat-Robert
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引用次数: 6

摘要

动脉粥样硬化过程始于弹性纤维的降解。它们在循环中存在,并阐明了它们的一些生物学特性。多年前,我们描述了一种通过有机碱性水解获得大弹性蛋白肽的方法,即κ-弹性蛋白。该方法还可以制备用于测定体液和组织提取物中弹性蛋白肽以及抗弹性蛋白抗体的特异性抗体。在大量人体血液样本中测定了弹性蛋白肽。对其药理特性进行了研究。其他实验室最近的类似研究证实了我们的发现,并对循环弹性蛋白肽的生物活性产生了新的兴趣。这一最近的趋势证明了在我们之前的研究中所证明的弹性蛋白肽的生物学和病理活性的评论的出版是合理的,这篇文章的主题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Circulating elastin peptides, role in vascular pathology

The atherosclerotic process starts with the degradation of elastic fibers. Their presence was demonstrated in the circulation as well as several of their biological properties elucidated. We described years ago a procedure to obtain large elastin peptides by organo-alkaline hydrolysis, κ-elastin. This method enabled also the preparation of specific antibodies used to determine elastin peptides, as well as anti-elastin antibodies in body fluids and tissue extracts. Elastin peptides were determined in a large number of human blood samples. Studies were carried out to explore their pharmacological properties. Similar recent studies by other laboratories confirmed our findings and arose new interest in circulating elastin peptides for their biological activities. This recent trend justified the publication of a review of the biological and pathological activities of elastin peptides demonstrated during our previous studies, subject of this article.

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来源期刊
Pathologie-biologie
Pathologie-biologie 医学-病理学
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6-12 weeks
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