癌症免疫治疗的临床实践——过去,现在和未来。

Q Medicine
癌症 Pub Date : 2014-09-01 DOI:10.5732/cjc.014.10123
Gaurav Goel, Weijing Sun
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引用次数: 34

摘要

近年来,肿瘤免疫治疗领域取得了长足的进展。这在很大程度上是由于新的基于免疫的细胞靶标的识别和旨在刺激免疫系统的新方法的发展而成为可能的。免疫抑制微环境在肿瘤发展中的作用已经确立。检查点抑制抗体和癌症疫苗的成功标志着癌症治疗新时代的开始。这篇综述强调了癌症免疫学的临床相关原则和各种免疫治疗方法,这些方法要么已经进入主流肿瘤学实践,要么正在临床试验中进行评估。此外,目前的障碍发展有效的免疫疗法和潜在的策略克服他们也进行了讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cancer immunotherapy in clinical practice -- the past, present, and future.

Considerable progress has been made in the field of cancer immunotherapy in recent years. This has been made possible in large part by the identification of new immune-based cellular targets and the development of novel approaches aimed at stimulating the immune system. The role played by the immunosuppressive microenvironment in the development of tumors has been established. The success of checkpoint-inhibiting antibodies and cancer vaccines has marked the beginning of a new era in cancer treatment. This review highlights the clinically relevant principles of cancer immunology and various immunotherapeutic approaches that have either already entered mainstream oncologic practice or are currently in the process of being evaluated in clinical trials. Furthermore, the current barriers to the development of effective immunotherapies and the potential strategies of overcoming them are also discussed.

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来源期刊
癌症
癌症 ONCOLOGY-
CiteScore
3.47
自引率
0.00%
发文量
9010
审稿时长
12 weeks
期刊介绍: In July 2008, Landes Bioscience and Sun Yat-sen University Cancer Center began co-publishing the international, English-language version of AI ZHENG or the Chinese Journal of Cancer (CJC). CJC publishes original research, reviews, extra views, perspectives, supplements, and spotlights in all areas of cancer research. The primary criteria for publication in CJC are originality, outstanding scientific merit, and general interest. The Editorial Board is composed of members from around the world, who will strive to maintain the highest standards for excellence in order to generate a valuable resource for an international readership.
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