甲状旁腺功能减退症的骨病。

Bart L Clarke
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引用次数: 20

摘要

甲状旁腺功能减退症是一种罕见的疾病,可获得或遗传。术后甲状旁腺功能减退是获得性甲状旁腺功能减退的主要原因。骨疾病发生在甲状旁腺功能减退症,由于甲状旁腺激素的缺乏或低水平导致骨重塑明显减少。甲状旁腺功能减退症患者的骨转换长期减少通常导致骨量高于年龄和性别匹配的对照组。骨密度的增加是否会降低骨折风险尚不确定,因为虽然骨矿化增加可能与骨脆性增加有关,但甲状旁腺功能减退症似乎并非如此。重组甲状旁腺激素治疗甲状旁腺功能低下可降低骨密度,同时增强骨的力学性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bone disease in hypoparathyroidism.

Hypoparathyroidism is a rare disorder that may be acquired or inherited. Postsurgical hypoparathyroidism is responsible for the majority of acquired hypoparathyroidism. Bone disease occurs in hypoparathyroidism due to markedly reduced bone remodeling due to the absence or low levels of parathyroid hormone. Chronically reduced bone turnover in patients with hypoparathyroidism typically leads to higher bone mass than in age- and sex-matched controls. Whether this increased bone density reduces fracture risk is less certain, because while increased bone mineralization may be associated with increased brittleness of bone, this does not appear to be the case in hypoparathyroidism. Treatment of hypoparathyroidism with recombinant parathyroid hormone may reduce bone mineral density but simultaneously strengthen the mechanical properties of bone.

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