tolperisone的药效学基本方面，一种广泛应用的中枢作用肌肉松弛剂。

Q2 Pharmacology, Toxicology and Pharmaceutics

Open Medicinal Chemistry Journal Pub Date : 2014-07-11 eCollection Date: 2014-01-01 DOI:10.2174/1874104501408010017

Kornelia Tekes

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引用次数: 19

摘要

托哌立酮(2-甲基-1-(4-甲基苯基)-3-哌啶-1-基丙烷-1- 1-氯化氢)于四十多年前被引入临床实践，至今仍被认为是一种广泛应用于病理性骨骼肌张力升高(痉挛)和不同来源的相关疼痛的化合物。本文就其在动物体内的基本药效学效应、对细胞和组织制剂的作用分析以及对钠钙通道的分子机制等方面的研究进展作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Basic aspects of the pharmacodynamics of tolperisone, a widely applicable centrally acting muscle relaxant.

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Basic aspects of the pharmacodynamics of tolperisone, a widely applicable centrally acting muscle relaxant.

Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the clinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevated skeletal muscle tone (spasticity) and related pains of different origin. In the present review, basic pharmacodynamic effects measured on whole animals, analyses of its actions on cell and tissue preparations and molecular mechanism of action on sodium and calcium channels are summarized as recently significantly new data were reported.

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来源期刊

Open Medicinal Chemistry Journal Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.40

自引率

0.00%

发文量