{"title":"作为潜在前药的酯连接的2-苯基吲哚-3-羧醛-单糖缀合物的化学酶合成。","authors":"Kei Shimoda, Manabu Hamada, Hiroshi Yokoi, Hiroki Hamada","doi":"10.4137/BCI.S9961","DOIUrl":null,"url":null,"abstract":"<p><p>Chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-glucose conjugate (2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester) was achieved by using plant cell cultures as biocatalysts. The anticancer agent, 2-phenylindole-3-carboxaldehyde, induced apoptosis in cells, whereas 2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester showed no cytotoxicity and induced no apoptosis. </p>","PeriodicalId":8791,"journal":{"name":"Biochemistry Insights","volume":"5 ","pages":"17-20"},"PeriodicalIF":0.0000,"publicationDate":"2012-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/BCI.S9961","citationCount":"1","resultStr":"{\"title\":\"Chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-monosaccharide conjugate as potential prodrug.\",\"authors\":\"Kei Shimoda, Manabu Hamada, Hiroshi Yokoi, Hiroki Hamada\",\"doi\":\"10.4137/BCI.S9961\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-glucose conjugate (2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester) was achieved by using plant cell cultures as biocatalysts. The anticancer agent, 2-phenylindole-3-carboxaldehyde, induced apoptosis in cells, whereas 2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester showed no cytotoxicity and induced no apoptosis. </p>\",\"PeriodicalId\":8791,\"journal\":{\"name\":\"Biochemistry Insights\",\"volume\":\"5 \",\"pages\":\"17-20\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-08-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.4137/BCI.S9961\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochemistry Insights\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4137/BCI.S9961\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2012/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry Insights","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4137/BCI.S9961","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2012/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
以植物细胞培养物为生物催化剂，化学酶法合成了酯连接的2-苯基吲哚-3-羧基-葡萄糖偶联物(2-苯基吲哚-3-羧基-10″-O-β- d -葡萄糖酯)。抗肿瘤剂2-苯基吲哚-3-羧基-10″-O-β- d -葡萄糖基酯对细胞无细胞毒性，且不诱导细胞凋亡。
Chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-monosaccharide conjugate as potential prodrug.
Chemo-enzymatic synthesis of ester-linked 2-phenylindole-3-carboxaldehyde-glucose conjugate (2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester) was achieved by using plant cell cultures as biocatalysts. The anticancer agent, 2-phenylindole-3-carboxaldehyde, induced apoptosis in cells, whereas 2-phenylindole-3-carboxyl-10″-O-β-D-glucosyl ester showed no cytotoxicity and induced no apoptosis.
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