behet病患者血清血管抑制素水平:血管生成在behet病的发病机制中起作用吗?

IF 1.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
D Keskin, G Keskin, A Inal, L Ozışık
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引用次数: 9

摘要

血管生成在炎症性疾病的发病机制中起着重要作用,但血管生成在behet病(BD)中的可能作用尚未得到研究。本研究的目的是确定BD患者的血管抑制素水平以及血管生成在该疾病发病机制中的作用。37例BD患者(平均年龄:28.6±5.4岁,平均病程:9.3±3.7年)和18名健康对照者纳入研究。24例处于活跃期,13例处于非活跃期。BD患者血清血管抑制素平均水平为113·9±53.2 ng/ml,健康对照组为60·7±20.1 ng/ml。活动性BD患者血清血管抑制素水平平均为142·7±43·1 ng/ml,非活动性BD患者血清血管抑制素水平平均为86·9±15·5 ng/ml
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum angiostatin levels in patients with Behçet's disease: does angiogenesis play a role in the pathogenesis of Behçet's disease?

Angiogenesis plays an important role in the pathogenesis of inflammatory diseases, but the possible role of angiogenesis in Behçet's disease (BD) has not yet been studied. The aim of this study was to determine angiostatin levels in patients with BD and the role of angiogenesis in the pathogenesis of the disease. Thirty-seven patients with BD (mean age: 28·6±5·4 years, mean disease duration: 9·3±3·7 years) and 18 healthy controls were enrolled to the study. Twenty-four patients were in active and 13 patients were in inactive stage of the disease. The mean serum angiostatin level of patients with BD was 113·9±53·2 and 60·7±20·1 ng/ml in healthy controls. The mean serum angiostatin level was 142·7±43·1 ng/ml in active and 86·9±15·5 ng/ml in inactive patients with BD. Serum angiostatin levels were significantly high in patients with BD compared with healthy controls (P<0·001) and it was significantly high in active patients compared with inactive patients with BD (P<0·001). In inactive patients with BD, serum angiostatin concentrations were found to be higher compared with healthy controls (P<0·01). In active BD patients, the mean serum angiostatin level was correlated with the deep vein thrombosis (r = 0·482, P = 0·05), uveitis (r = 0·582, P = 0·01), and arthritis (r = 0·492, P = 0·05). According to these results; elevated serum angiostatin levels in patients with BD suggest the possible role of angiogenesis in the pathogenesis of the disease and its high levels in inactive Behçet's patients is related with the continuous activation of the disease even in the subclinical period.

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来源期刊
Acta Clinica Belgica
Acta Clinica Belgica MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
0.00%
发文量
44
期刊介绍: Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine primarily publishes papers on clinical medicine, clinical chemistry, pathology and molecular biology, provided they describe results which contribute to our understanding of clinical problems or describe new methods applicable to clinical investigation. Readership includes physicians, pathologists, pharmacists and physicians working in non-academic and academic hospitals, practicing internal medicine and its subspecialties.
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