TRPV1在中枢神经系统中的作用:突触可塑性、功能和药理意义。

Jeffrey G Edwards
{"title":"TRPV1在中枢神经系统中的作用:突触可塑性、功能和药理意义。","authors":"Jeffrey G Edwards","doi":"10.1007/978-3-0348-0828-6_3","DOIUrl":null,"url":null,"abstract":"<p><p>The function of TRPV1 in the peripheral nervous system is increasingly being investigated for its anti-inflammatory and antinociceptive properties in an effort to find a novel target to fight pain that is nonaddictive. However, in recent years, it was discovered that TRPV1 is also associated with a wide array of functions and behaviors in the central nervous system, such as fear, anxiety, stress, thermoregulation, pain, and, more recently, synaptic plasticity, the cellular mechanism that allows the brain to adapt to its environment. This suggests a new role for brain TRPV1 in areas such as learning and memory, reward and addiction, and development. This wide array of functional aspects of TRPV1 in the central nervous system (CNS) is in part due to its multimodal form of activation and highlights the potential pharmacological implications of TRPV1 in the brain. As humans also express a TRPV1 homologue, it is likely that animal research will be translational to humans and therefore worthy of exploration. This review outlines the basic expression patterns of TRPV1 in the CNS along with what is known regarding its signaling mechanisms and its role in the aforementioned brain functions. As TRPV1 involvement in synaptic plasticity has never been fully reviewed elsewhere, it will be a focus of this review. The chapter concludes with some of the potential pharmaceutical implications of further TRPV1 research.</p>","PeriodicalId":20603,"journal":{"name":"Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques","volume":"68 ","pages":"77-104"},"PeriodicalIF":0.0000,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-0348-0828-6_3","citationCount":"76","resultStr":"{\"title\":\"TRPV1 in the central nervous system: synaptic plasticity, function, and pharmacological implications.\",\"authors\":\"Jeffrey G Edwards\",\"doi\":\"10.1007/978-3-0348-0828-6_3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The function of TRPV1 in the peripheral nervous system is increasingly being investigated for its anti-inflammatory and antinociceptive properties in an effort to find a novel target to fight pain that is nonaddictive. However, in recent years, it was discovered that TRPV1 is also associated with a wide array of functions and behaviors in the central nervous system, such as fear, anxiety, stress, thermoregulation, pain, and, more recently, synaptic plasticity, the cellular mechanism that allows the brain to adapt to its environment. This suggests a new role for brain TRPV1 in areas such as learning and memory, reward and addiction, and development. This wide array of functional aspects of TRPV1 in the central nervous system (CNS) is in part due to its multimodal form of activation and highlights the potential pharmacological implications of TRPV1 in the brain. As humans also express a TRPV1 homologue, it is likely that animal research will be translational to humans and therefore worthy of exploration. This review outlines the basic expression patterns of TRPV1 in the CNS along with what is known regarding its signaling mechanisms and its role in the aforementioned brain functions. As TRPV1 involvement in synaptic plasticity has never been fully reviewed elsewhere, it will be a focus of this review. The chapter concludes with some of the potential pharmaceutical implications of further TRPV1 research.</p>\",\"PeriodicalId\":20603,\"journal\":{\"name\":\"Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques\",\"volume\":\"68 \",\"pages\":\"77-104\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/978-3-0348-0828-6_3\",\"citationCount\":\"76\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/978-3-0348-0828-6_3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/978-3-0348-0828-6_3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 76

摘要

TRPV1在外周神经系统中的功能正因其抗炎和抗痛觉特性而受到越来越多的研究,以寻找一种非成瘾性的新靶点来对抗疼痛。然而,近年来,人们发现TRPV1还与中枢神经系统的一系列功能和行为有关,如恐惧、焦虑、压力、体温调节、疼痛,以及最近的突触可塑性,这是一种允许大脑适应环境的细胞机制。这表明大脑TRPV1在学习和记忆、奖励和成瘾以及发展等领域发挥了新的作用。TRPV1在中枢神经系统(CNS)中广泛的功能方面部分是由于其多模态激活形式,并突出了TRPV1在大脑中的潜在药理意义。由于人类也表达TRPV1同源物,因此动物研究很可能会转化为人类,因此值得探索。本文概述了TRPV1在中枢神经系统中的基本表达模式,以及已知的信号机制及其在上述脑功能中的作用。由于TRPV1参与突触可塑性的研究尚未在其他地方得到全面的报道,因此本文将对其进行重点综述。本章总结了进一步研究TRPV1的一些潜在的药学意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
TRPV1 in the central nervous system: synaptic plasticity, function, and pharmacological implications.

The function of TRPV1 in the peripheral nervous system is increasingly being investigated for its anti-inflammatory and antinociceptive properties in an effort to find a novel target to fight pain that is nonaddictive. However, in recent years, it was discovered that TRPV1 is also associated with a wide array of functions and behaviors in the central nervous system, such as fear, anxiety, stress, thermoregulation, pain, and, more recently, synaptic plasticity, the cellular mechanism that allows the brain to adapt to its environment. This suggests a new role for brain TRPV1 in areas such as learning and memory, reward and addiction, and development. This wide array of functional aspects of TRPV1 in the central nervous system (CNS) is in part due to its multimodal form of activation and highlights the potential pharmacological implications of TRPV1 in the brain. As humans also express a TRPV1 homologue, it is likely that animal research will be translational to humans and therefore worthy of exploration. This review outlines the basic expression patterns of TRPV1 in the CNS along with what is known regarding its signaling mechanisms and its role in the aforementioned brain functions. As TRPV1 involvement in synaptic plasticity has never been fully reviewed elsewhere, it will be a focus of this review. The chapter concludes with some of the potential pharmaceutical implications of further TRPV1 research.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信