移植物成分对造血干细胞移植后患者预后的影响:表达CCR7的移植物中CD4+ T淋巴细胞比例与急性GVH发生的相关性

B. Choufi , S. Thiant , J. Trauet , M. Cliquennois , M. Cherrel , F. Boulanger , V. Coiteux , L. Magro , M. Labalette , I. Yakoub-Agha
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引用次数: 7

摘要

在之前的一项对62例接受hla匹配异体干细胞移植的患者的前瞻性研究中,我们观察到移植物中供体来源的CCR7+/CD4+ T细胞的比例提供了急性GVHD的预测指标,而不干扰慢性GVHD和复发率。在这里,我们提出了137例连续患者的验证性队列研究结果。事实上,在移植物中接受超过76%的CCR7+/CD4+ T细胞的患者,无论是低级别还是高级别,都比没有接受移植的患者更容易发生急性GVHD。测定移植物中CD4+ T细胞的CCR7+/CCR7阴性比率提供了急性GVHD的预测指标,并有助于确定部分选择性T细胞耗尽移植的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact de la composition du greffon sur le devenir des patients après une allogreffe de cellules souches hématopoïétiques : corrélation entre proportion des lymphocytes T CD4+ du greffon exprimant le CCR7 et la survenue d’une GVH aiguë

In a previous prospective study on 62 patients who underwent an HLA-matched allogeneic stem cell transplantation, we have observed that proportion of donor-derived CCR7+/CD4+ T cells in the graft provided a predictive indicator of acute GVHD without interfering on chronic GVHD and relapse rate. Here we present our results on a confirmatory cohort of 137 consecutive patients. Indeed patients who received more than 76% of CCR7+/CD4+ T cells in the graft developed more often acute GVHD be it of low or high grade than those who did not. Determination of the CCR7+/CCR7neg ratio of CD4+ T cells in the graft provides a predictive indicator of acute GVHD and could help to define strategies of partial selective T cell depleted transplantation.

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来源期刊
Pathologie-biologie
Pathologie-biologie 医学-病理学
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