重度-地中海贫血患者血清肌钙蛋白和铁蛋白水平的相关性研究。

IF 0.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Iraj Shahramian, Motahhare Razzaghian, Abbas Ali Ramazani, Ghasem Ali Ahmadi, Noor Mohammad Noori, Ali Reza Rezaee
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引用次数: 0

摘要

背景:地中海贫血是一种遗传性血红蛋白病,其最常见的并发症是累及心脏,最终导致患者死亡。由于肌钙蛋白是检测微梗死的敏感和特异性标志物,我们研究了肌钙蛋白和铁蛋白血清水平之间的关系,以早期诊断这些患者的心脏受累。材料与方法:本病例对照研究共80例患者,其中重型地中海贫血超声心动图正常患者40例,健康志愿者40例,年龄6个月~ 16岁。对所有儿童进行检查,并在获得父母的书面知情同意后,将未感染已知心脏病、缺铁性贫血、肾病、糖尿病、发热和全身性疾病的符合条件的儿童纳入研究。早上8点早餐前,从这些孩子身上抽取了5cc的血。采集标本后,分别用ELISA法和电单核苷酸法测定血清铁蛋白和肌钙蛋白水平。收集到的数据通过SPSS统计软件(v. 20)和t检验进行分析。结果:两组患者血清肌钙蛋白(P=0.045)和铁蛋白(P=0.001)水平均值差异有统计学意义。在本研究中,两组患者血清肌钙蛋白和铁蛋白水平与年龄和BMI均无显著相关性。血清肌钙蛋白水平与性别无显著相关(P=0.264)。结论:在微梗死中,肌钙蛋白的增加不依赖于铁蛋白;因此,可用于地中海贫血患者心脏受累的早期检测,确定亚临床效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Correlation between Troponin and Ferritin Serum Levels in the Patients with Major Beta-Thalassemia.

Background: Thalassemia is a hereditary hemoglobinopathy whose most common complication is cardiac involvement which ends up in these patients' death. Since troponin is a sensitive and specific marker for the detection of microinfarct, we studied the relationship between troponin and ferritin serum levels for early diagnosis of cardiac involvement in these patients.

Materials and methods: This case-control study was performed on 80 patients, including 40 patients with major thalassemia and normal echocardiography and 40 healthy volunteers ranging from 6 months to 16 years old. All the children were examined and the eligible children who were not infected with known heart disease, iron deficiency anemia, kidney disease, diabetes, fever, and systemic diseases were enrolled into the study after obtaining written informed consents from their parents. At 8:00 A.M. before breakfast, 5cc blood was drawn from these children. After collecting the samples, ferritin and troponin serum levels were evaluated using ELISA and electro- kymonolonsense methods, respectively. The gathered data were analyzed through the SPSS statistical software (v. 20) and T-test. Besides, P value<0.05 was considered as statistically significant.

Results: The study results revealed a significant difference between the two groups regarding the mean of the serum levels of troponin (P=0.045) and ferritin (P=0.001). In this study, no significant correlation was observed between serum troponin and ferritin levels and age and BMI in the two groups. Also, no significant relationship was found between serum troponin level and sex (P=0.264).

Conclusions: In microinfarct, troponin increases independent of ferritin; therefore, it can be used for early detection of cardiac involvement in thalassemia patients to determine the sub-clinical effects.

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来源期刊
International Cardiovascular Research Journal
International Cardiovascular Research Journal CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
0.40
自引率
50.00%
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