Carlos Augusto Nassar, Guilherme Degani Battistetti, Flávia Pardo Salata Nahsan, Joice Olegário, Juliana Marconato, Caroline Fernandes Marin, Daniele Marin Faccioni, Karine Figueiredo da Costa, Luciana Bill Mikito Kottwitz, Patricia Oehlmeyer Nassar
{"title":"辛伐他汀对实验性牙周炎患者牙槽骨丢失进展影响的动物研究","authors":"Carlos Augusto Nassar, Guilherme Degani Battistetti, Flávia Pardo Salata Nahsan, Joice Olegário, Juliana Marconato, Caroline Fernandes Marin, Daniele Marin Faccioni, Karine Figueiredo da Costa, Luciana Bill Mikito Kottwitz, Patricia Oehlmeyer Nassar","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>The aim of the present study was to evaluate the effect of simvastatin, a potent antiinflammatory drug, on the progression of alveolar bone loss in an experimental model of periodontitis in rats.</p><p><strong>Material and methods: </strong>A cotton ligature was used around the lower right first molar in a submarginal position in order to induce experimental periodontitis. Sixty rats were divided into 12 groups consisting of three control groups, three simvastatin groups, three ligature groups, and three ligature plus simvastatin groups. The distance between the cemento-enamel junction and the alveolar crest was determined at the mesial root surfaces of the lower right first molars by radiographic as well as profilometric analyses.</p><p><strong>Results: </strong>In rats of the experimental periodontitis group (ligature), alveolar bone loss was higher compared to the control groups. However, simvastatin was associated with decreased alveolar bone loss in all treatment groups with experimental periodontitis (p < 0.01).</p><p><strong>Conclusion: </strong>Simvastatin treatment seems to be a beneficial and supporting therapeutic that favors protection against alveolar bone loss in a model of experimental periodontitis in rats.</p>","PeriodicalId":17281,"journal":{"name":"Journal of the International Academy of Periodontology","volume":"16 1","pages":"2-7"},"PeriodicalIF":0.0000,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of the effect of simvastatin on the progression of alveolar bone loss in experimental periodontitis--an animal study.\",\"authors\":\"Carlos Augusto Nassar, Guilherme Degani Battistetti, Flávia Pardo Salata Nahsan, Joice Olegário, Juliana Marconato, Caroline Fernandes Marin, Daniele Marin Faccioni, Karine Figueiredo da Costa, Luciana Bill Mikito Kottwitz, Patricia Oehlmeyer Nassar\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>The aim of the present study was to evaluate the effect of simvastatin, a potent antiinflammatory drug, on the progression of alveolar bone loss in an experimental model of periodontitis in rats.</p><p><strong>Material and methods: </strong>A cotton ligature was used around the lower right first molar in a submarginal position in order to induce experimental periodontitis. Sixty rats were divided into 12 groups consisting of three control groups, three simvastatin groups, three ligature groups, and three ligature plus simvastatin groups. The distance between the cemento-enamel junction and the alveolar crest was determined at the mesial root surfaces of the lower right first molars by radiographic as well as profilometric analyses.</p><p><strong>Results: </strong>In rats of the experimental periodontitis group (ligature), alveolar bone loss was higher compared to the control groups. However, simvastatin was associated with decreased alveolar bone loss in all treatment groups with experimental periodontitis (p < 0.01).</p><p><strong>Conclusion: </strong>Simvastatin treatment seems to be a beneficial and supporting therapeutic that favors protection against alveolar bone loss in a model of experimental periodontitis in rats.</p>\",\"PeriodicalId\":17281,\"journal\":{\"name\":\"Journal of the International Academy of Periodontology\",\"volume\":\"16 1\",\"pages\":\"2-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the International Academy of Periodontology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the International Academy of Periodontology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evaluation of the effect of simvastatin on the progression of alveolar bone loss in experimental periodontitis--an animal study.
Aim: The aim of the present study was to evaluate the effect of simvastatin, a potent antiinflammatory drug, on the progression of alveolar bone loss in an experimental model of periodontitis in rats.
Material and methods: A cotton ligature was used around the lower right first molar in a submarginal position in order to induce experimental periodontitis. Sixty rats were divided into 12 groups consisting of three control groups, three simvastatin groups, three ligature groups, and three ligature plus simvastatin groups. The distance between the cemento-enamel junction and the alveolar crest was determined at the mesial root surfaces of the lower right first molars by radiographic as well as profilometric analyses.
Results: In rats of the experimental periodontitis group (ligature), alveolar bone loss was higher compared to the control groups. However, simvastatin was associated with decreased alveolar bone loss in all treatment groups with experimental periodontitis (p < 0.01).
Conclusion: Simvastatin treatment seems to be a beneficial and supporting therapeutic that favors protection against alveolar bone loss in a model of experimental periodontitis in rats.
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