利用噬菌体对抗耐药细菌的不同方法。

Bacteriophage Pub Date : 2014-01-01 Epub Date: 2014-03-11 DOI:10.4161/bact.28491
Ido Yosef, Ruth Kiro, Shahar Molshanski-Mor, Rotem Edgar, Udi Qimron
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引用次数: 23

摘要

细菌对抗生素的耐药性是一个需要紧急解决的新威胁。自发现以来,溶解噬菌体一直被认为是治疗药物,但其应用面临各种障碍:噬菌体被脾脏和肝脏隔离,针对噬菌体的抗体,宿主范围窄,不易接近感染组织,细菌耐药。已经提出了噬菌体使用的变化,例如将温带噬菌体作为基因递送载体进入病原体。这种方法,这是提出致敏病原体驻留在医院表面和医务人员的皮肤,其前景在本附录中描述。此外,噬菌体编码产物已被提出作为对抗细菌抗生素耐药性的武器。我们描述了在T7噬菌体的基础研究中发现的一种新的噬菌体蛋白。这种蛋白质可能偶然地被证明对治疗耐抗生素病原体有用。我们相信,进一步的基础研究将导致对抗抗生素耐药细菌的新策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Different approaches for using bacteriophages against antibiotic-resistant bacteria.

Bacterial resistance to antibiotics is an emerging threat requiring urgent solutions. Ever since their discovery, lytic bacteriophages have been suggested as therapeutic agents, but their application faces various obstacles: sequestration of the phage by the spleen and liver, antibodies against the phage, narrow host range, poor accessibility to the infected tissue, and bacterial resistance. Variations on bacteriophage use have been suggested, such as temperate phages as gene-delivery vehicles into pathogens. This approach, which is proposed to sensitize pathogens residing on hospital surfaces and medical personnel's skin, and its prospects are described in this addendum. Furthermore, phage-encoded products have been proposed as weapons against antibiotic resistance in bacteria. We describe a new phage protein which was identified during basic research into T7 bacteriophages. This protein may serendipitously prove useful for treating antibiotic-resistant pathogens. We believe that further basic research will lead to novel strategies in the fight against antibiotic-resistant bacteria.

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