坏死性下垂:分子信号传导和翻译意义。

Q3 Biochemistry, Genetics and Molecular Biology

International Journal of Cell Biology Pub Date : 2014-01-01 Epub Date: 2014-01-23 DOI:10.1155/2014/490275

Claudia Giampietri, Donatella Starace, Simonetta Petrungaro, Antonio Filippini, Elio Ziparo

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引用次数: 60

摘要

坏死性坏死是一种程序性坏死，其分子机制与细胞凋亡部分相同。在这里，我们总结了已知的关于坏死坏死的分子信号传导，特别关注凋亡/坏死平衡中FLIP和IAP蛋白的微调。我们还强调坏死性下垂参与生理和病理条件，特别是在免疫稳态的调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Necroptosis: molecular signalling and translational implications.

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Necroptosis: molecular signalling and translational implications.

Necroptosis is a form of programmed necrosis whose molecular players are partially shared with apoptotic cell death. Here we summarize what is known about molecular signalling of necroptosis, particularly focusing on fine tuning of FLIP and IAP proteins in the apoptosis/necroptosis balance. We also emphasize necroptosis involvement in physiological and pathological conditions, particularly in the regulation of immune homeostasis.

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来源期刊

International Journal of Cell Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

20 weeks