遗忘性轻度认知障碍和阿尔茨海默病患者KIF6 719Arg携带者状态与同型半胱氨酸和c反应蛋白的关系

Q1 Neuroscience
International Journal of Alzheimer's Disease Pub Date : 2013-01-01 Epub Date: 2013-12-24 DOI:10.1155/2013/242303
Michael Malek-Ahmadi, Amar Patel, Marwan N Sabbagh
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引用次数: 2

摘要

最近的研究表明,他汀类药物的使用、kif6719arg载体状态、胆固醇水平、遗忘性轻度认知障碍(aMCI)和阿尔茨海默病(AD)患者之间存在关联。在aMCI和AD中,719Arg携带者状态与同型半胱氨酸(tHcy)和c反应蛋白(CRP)水平之间的关系尚未被研究。来自175名aMCI和AD患者的数据被用于分析。719例arg携带者tHcy水平显著低于非携带者(P = 0.02)。719Arg携带者与非携带者CRP水平无显著差异(P = 0.37)。在调整ApoE ε4携带者状态、年龄、性别和他汀类药物使用情况后,Logistic回归显示719Arg状态对CRP无显著影响[OR = 1.79 (0.85, 3.83), P = 0.13],但对tHcy有显著影响[OR = 0.44 (0.23, 0.83), P = 0.01]。本研究首次探讨了KIF6 719Arg携带者状态与tHcy和CRP水平之间的关系。在调整ApoE ε4状态、年龄、性别和他汀类药物使用后,arg携带者更有可能拥有正常的tHcy水平。这些结果表明KIF6基因可能影响与AD相关的心血管途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
KIF6 719Arg Carrier Status Association with Homocysteine and C-Reactive Protein in Amnestic Mild Cognitive Impairment and Alzheimer's Disease Patients.

Recent research has demonstrated associations between statin use, KIF6 719Arg carrier status, and cholesterol levels and amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) patients. The association between 719Arg carrier status with homocysteine (tHcy) and c-reactive protein (CRP) levels in aMCI and AD has not been previously investigated. Data from 175 aMCI and AD patients were used for the analysis. 719Arg carriers had significantly lower levels of tHcy than noncarriers (P = 0.02). No significant difference in CRP levels between 719Arg carriers and noncarriers was present (P = 0.37). Logistic regression yielded no significant effect for 719Arg status on CRP [OR = 1.79 (0.85, 3.83), P = 0.13] but did demonstrate a significant effect for tHcy [OR = 0.44 (0.23, 0.83), P = 0.01] after adjusting for ApoE ε4 carrier status, age, gender, and statin use. This study is the first to explore the relationship between KIF6 719Arg carrier status with tHcy and CRP levels. 719Arg carriers were more likely to have normal tHcy levels after adjusting for ApoE ε4 status, age, gender, and statin use. These results suggest that the KIF6 gene might influence cardiovascular pathways associated with AD.

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来源期刊
International Journal of Alzheimer's Disease
International Journal of Alzheimer's Disease Neuroscience-Behavioral Neuroscience
CiteScore
10.10
自引率
0.00%
发文量
3
审稿时长
11 weeks
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