γ-分泌酶调节剂:现状及未来发展方向

Q1 Pharmacology, Toxicology and Pharmaceutics

Progress in medicinal chemistry Pub Date : 2014-01-01 DOI:10.1016/B978-0-444-63380-4.00003-2

Adrian Hall, Toshal R Patel

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引用次数: 45

摘要

本章回顾了γ-分泌酶调节剂的现状，重点介绍了每个公司参与该领域的关键化合物。综述了三种主要的化学型:酸类、咪唑类及其衍生物和天然产物。还包括化学生物学和配体结合位点阐明研究的部分。信息的主要来源是从同行评审的文献中得出的，因为这允许分析PK-PD关系和随后的评论。为完整起见，还包括对专利文献的讨论。从这一分析中，突出了该领域的关键问题和挑战。本文总结了该领域的临床发展现状，并对其未来发展前景进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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γ-Secretase modulators: current status and future directions.

This chapter reviews the current status of γ-secretase modulators, highlighting key compounds by each company involved in the area. The review focuses on the three main chemotypes: acids, imidazoles and related derivatives and natural products. A section on chemical biology and ligand-binding site elucidation studies is also included. The primary source of information is drawn from peer reviewed literature as this permits analysis of PK-PD relationships and subsequent comment. Discussion of the patent literature is included for completeness. From this analysis, the key issues and challenges in the area are highlighted. The review concludes with a summary of the clinical development status and comment on future prospects of the field.

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来源期刊

Progress in medicinal chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

15.60

自引率

0.00%

发文量

期刊介绍： This series has a long established reputation for excellent coverage of almost every facet of Medicinal Chemistry and is one of the most respected and instructive sources of information on the subject. The latest volume certifies to the continuing success of a unique series reflecting current progress in a broadly developing field of science.