抑制抗逆转录病毒治疗的HIV感染者早期动脉粥样硬化:骨保护素的作用。

ISRN AIDS Pub Date : 2013-12-05 eCollection Date: 2013-01-01 DOI:10.1155/2013/737083
Alessandra D'Abramo, Claudia D'Agostino, Alessandra Oliva, Marco Iannetta, Gabriella D'Ettorre, Francesco Vullo, Massimo Mancone, Maria Rosa Ciardi, Claudio Maria Mastroianni, Vincenzo Vullo
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引用次数: 9

摘要

艾滋病毒感染患者的心血管疾病增加。细胞因子如骨保护素与动脉粥样硬化有关。本研究的目的是评估骨保护素在接受抑制性抗逆转录病毒治疗的HIV感染者动脉粥样硬化发生和进展中的作用。我们招募了76名患者;35名艾滋病毒感染者接受抑制性高活性抗逆转录病毒治疗Framingham得分10%作为对照组。HIV阳性受试者接受超声心动图、心电图和心脏多探测器计算机断层扫描,而HIV阴性受试者仅在超声心动图或心电图出现异常时才进行断层扫描。在HIV阳性患者中,计算机断层扫描显示51.4%的受试者狭窄。HIV感染患者的骨保护素血浆水平高于健康对照组,但低于Framingham评分>10%的HIV阴性受试者。I级狭窄的HIV阳性患者的血浆骨保护素水平高于II/III级狭窄的患者。综上所述,在HIV感染受试者中采用Framingham评分
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Early Atherosclerosis in HIV Infected Subjects on Suppressive Antiretroviral Treatment: Role of Osteoprotegerin.

Early Atherosclerosis in HIV Infected Subjects on Suppressive Antiretroviral Treatment: Role of Osteoprotegerin.

Early Atherosclerosis in HIV Infected Subjects on Suppressive Antiretroviral Treatment: Role of Osteoprotegerin.

Early Atherosclerosis in HIV Infected Subjects on Suppressive Antiretroviral Treatment: Role of Osteoprotegerin.
Cardiovascular disease is increased in HIV-infected patients. Cytokines such as osteoprotegerin are implicated in atherosclerosis. The aim of our study was to evaluate the role of osteoprotegerin in the development and progression of atherosclerosis in HIV infected subjects on suppressive antiretroviral treatment. We enrolled 76 patients; 35 HIV infected men on suppressive Highly Active Antiretroviral Therapy with Framingham score <10%; 21 HIV negative individuals matched for age, gender, and Framingham score, and 20 subjects with Framingham score >10% as control groups. HIV positive subjects underwent echocardiography, electrocardiography, and heart multidetector computed tomography, whereas in HIV negative subjects, tomography was only performed in case of any abnormalities either in echocardiography or electrocardiography. In HIV positive patients, computed tomography showed stenosis in 51.4% of the subjects. Osteoprotegerin plasma levels were higher in HIV-infected patients than those in healthy controls but lower than in HIV negative subjects with Framingham score >10%. Higher osteoprotegerin plasma levels were found in HIV positive patients with grade I stenosis than in patients with grade II/III stenosis. In conclusion, in HIV infected subjects with Framingham score <10%, osteoprotegerin plasma concentrations are associated with atherosclerosis, in particular at the early stage of the process.
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