Guro Aune , Astrid Kamilla Stunes , Aina-Mari Lian , Janne Elin Reseland , Solveig Tingulstad , Sverre H. Torp , Unni Syversen
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引用次数: 17
摘要
血清中几种细胞因子水平升高在卵巢癌中有报道。我们之前已经发现肝细胞生长因子(HGF)的诊断和预后价值。本研究的目的是评估多种血清细胞因子在卵巢肿瘤女性患者中的诊断和预后价值，并检查血清细胞因子水平与先前分析的HGF之间的可能关联。采用血清免疫分析法对113例盆腔肿块患者(57例为癌，23例为交界性肿瘤，33例为良性卵巢肿瘤)术前多种细胞因子水平进行定量分析。结果与临床病理参数有关。对5年总生存率进行单因素和多因素分析。卵巢癌患者术前血清癌抗原125 (CA 125)、白细胞介素8 (IL-8)、纤溶酶原激活物抑制剂-1 (PAI-1)水平明显高于卵巢良性肿瘤患者。血清IL-8、PAI-1水平与血清HGF水平呈正相关。在5年总生存率的多变量分析中，IL-8对预后有影响。与良性卵巢肿瘤患者相比，卵巢癌患者血清IL-8和PAI-1水平升高，且与卵巢肿瘤患者血清HGF水平呈正相关。IL-8似乎也有预后影响。
Circulating interleukin-8 and plasminogen activator inhibitor-1 are increased in women with ovarian carcinoma
Elevated serum levels of several cytokines have been reported in ovarian cancer. We have previously found a diagnostic and prognostic value of hepatocyte growth factor (HGF).
The aims of this study were to evaluate the diagnostic and prognostic value of multiple serum cytokines in women with ovarian tumors, and to examine possible associations between serum levels of cytokines and the previously analyzed HGF. Preoperative levels of multiple cytokines were quantified by serum-based immunoassays in 113 women with a pelvic mass: 57 carcinomas, 23 borderline tumors, and 33 benign ovarian tumors. The results were related to clinicopathological parameters. Univariate and multivariate analyses of five-year overall survival were performed.
The women with ovarian carcinoma had significantly higher preoperative serum levels of cancer antigen 125 (CA 125), interleukin 8 (IL-8), and plasminogen activator inhibitor-1 (PAI-1) than women with benign ovarian tumors. Serum IL-8 and PAI-1 levels were positively correlated to serum levels of HGF. In a multivariate analysis of five-year overall survival, IL-8 had a prognostic impact.
Serum levels of IL-8 and PAI-1 were elevated in women with ovarian carcinoma compared to women with benign ovarian tumors, and positively correlated to serum HGF levels in women with ovarian tumors. IL-8 also seemed to have a prognostic impact.
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