{"title":"神经胶质细胞中的P2X受体。","authors":"Alexei Verkhratsky, Yuri Pankratov, Ulyana Lalo, Maiken Nedergaard","doi":"10.1002/wmts.12","DOIUrl":null,"url":null,"abstract":"<p><p>Different types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling. Cortical astrocytes express specific P2X<sub>1/5</sub> heteromeric receptors that are activated by ongoing synaptic transmission and can trigger fast local signaling through elevation in cytoplasmic Ca<sup>2+</sup> and Na<sup>+</sup> concentrations. Oligodendrocytes express several types of P2X receptors that may control their development and mediate axonal-glial interactions. In microglia, P2X<sub>4</sub> and P2X<sub>7</sub> receptors regulate numerous events associated with microglial activation, motility, and release of proinflammatory factors.</p>","PeriodicalId":89646,"journal":{"name":"Wiley interdisciplinary reviews. Membrane transport and signaling","volume":"1 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/wmts.12","citationCount":"28","resultStr":"{\"title\":\"P2X receptors in neuroglia.\",\"authors\":\"Alexei Verkhratsky, Yuri Pankratov, Ulyana Lalo, Maiken Nedergaard\",\"doi\":\"10.1002/wmts.12\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Different types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling. Cortical astrocytes express specific P2X<sub>1/5</sub> heteromeric receptors that are activated by ongoing synaptic transmission and can trigger fast local signaling through elevation in cytoplasmic Ca<sup>2+</sup> and Na<sup>+</sup> concentrations. Oligodendrocytes express several types of P2X receptors that may control their development and mediate axonal-glial interactions. In microglia, P2X<sub>4</sub> and P2X<sub>7</sub> receptors regulate numerous events associated with microglial activation, motility, and release of proinflammatory factors.</p>\",\"PeriodicalId\":89646,\"journal\":{\"name\":\"Wiley interdisciplinary reviews. Membrane transport and signaling\",\"volume\":\"1 2\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/wmts.12\",\"citationCount\":\"28\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Wiley interdisciplinary reviews. Membrane transport and signaling\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/wmts.12\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Wiley interdisciplinary reviews. Membrane transport and signaling","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/wmts.12","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Different types of ionotropic P2X purinoceptors are expressed in all major types of neuroglia, where they mediate a variety of physiological and pathological signaling. Cortical astrocytes express specific P2X1/5 heteromeric receptors that are activated by ongoing synaptic transmission and can trigger fast local signaling through elevation in cytoplasmic Ca2+ and Na+ concentrations. Oligodendrocytes express several types of P2X receptors that may control their development and mediate axonal-glial interactions. In microglia, P2X4 and P2X7 receptors regulate numerous events associated with microglial activation, motility, and release of proinflammatory factors.
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