Hypersecretory villous adenoma as the primary cause of an intestinal intussusception and McKittrick-Wheelock syndrome.

Intestinal invagination or intussusception is the most common cause of intestinal obstruction in children and represent 5% of adult cases. This intestinal obstruction is due to a lesion in the intestinal mucosa that initiates intussusception or intestinal invagination (90% of adult cases are malignant). Moreover, villous adenomas, which represent malignant potential, are found within these lesions of intestinal mucosa. There are variants of villous adenomas known as hypersecretory adenomas, which are described as intestinal lesions located more frequently in the rectum and distal colon. In addition, these variant adenomas can cause hypersecretory diarrhea and an electrolyte disturbance known as McKittrick-Wheelock syndrome.