中间注射催产素抑制雏鸡的摄食行为

Kazuya Masunari , Md. Sakirul Islam Khan , Mark A. Cline , Tetsuya Tachibana
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引用次数: 26

摘要

中催产素(MT)是包括鸡在内的非哺乳动物脊椎动物的一种神经垂体激素,是哺乳动物中催产素(OT)的同源物。催产素是哺乳动物中一种众所周知的生殖激素,但其在鸡体内的生理作用尚不清楚。OT被认为可以调节哺乳动物的摄食行为,因为中枢和外周注射OT会抑制哺乳动物的摄食行为。另一方面,在禽类中,MT对摄食调节的作用尚未明确。因此,本研究旨在探讨MT是否与雏鸡(Gallus Gallus)的摄食调节有关。脑室注射MT显著降低雏鸡采食量,而腹腔注射则无显著影响。行为学观察显示,注射ICV后,MT的扑翅和整理行为显著增加,且有增加自主运动的趋势,提示MT的厌氧性作用可能与应激反应有关。但ICV注射MT对间脑血浆皮质酮浓度和促肾上腺皮质激素释放激素(CRH) mRNA表达均无影响。ICV注射CRH对间脑MT mRNA表达无影响。总之,中心注射MT与雏鸡的厌氧性反应有关,而厌氧性反应并不依赖于CRH。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Central administration of mesotocin inhibits feeding behavior in chicks

Mesotocin (MT) is a neurohypophysis hormone in non-mammalian vertebrates including chickens, and homologous of oxytocin (OT) in mammals. Oxytocin (OT) is a well known reproductive hormone in mammals, but the physiological roles of MT in chickens have not been clarified well. OT is thought to regulate feeding behavior because central and peripheral injections of OT inhibit feeding behavior in mammals. In avian, on the other hand, the effect of MT on feeding regulation has not yet been clarified. Therefore, the present study was carried out to examine whether MT is related to the regulation of feeding in chicks (Gallus gallus). Intracerebroventricular (ICV) injection of MT significantly decreased food intake in chicks while intraperitoneal injection had no effect. Behavioral observations revealed that ICV injection of MT significantly increased wing-flapping and preening, and tended to increase voluntary movement, implying that the anorexigenic effect of MT might be related to the stress response. However, neither plasma corticosterone concentration nor the mRNA expression of corticotrophin-releasing hormone (CRH) in the diencephalon was affected by ICV injection of MT. Moreover; ICV injection of CRH did not affect MT mRNA expression in the diencephalon. In sum, central injection of MT is associated with an anorexigenic response that does not appear CRH dependent in chicks.

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来源期刊
Regulatory Peptides
Regulatory Peptides 医学-内分泌学与代谢
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审稿时长
2 months
期刊介绍: Regulatory Peptides provides a medium for the rapid publication of interdisciplinary studies on the physiology and pathology of peptides of the gut, endocrine and nervous systems which regulate cell or tissue function. Articles emphasizing these objectives may be based on either fundamental or clinical observations obtained through the disciplines of morphology, cytochemistry, biochemistry, physiology, pathology, pharmacology or psychology.
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