{"title":"氯氮平引起的复发性和短暂性腮腺肿胀。","authors":"A Vohra","doi":"10.4314/ajpsy.v16i4.30","DOIUrl":null,"url":null,"abstract":"Clozapine is a novel dibenzodiazepine derivative, atypical antipsychotic which exhibits antagonistic activity on 5HT2, alpha 1, alpha 2, H1 and M1, M2, M3 and M5 receptors; agonist activity at the M4 muscarinic receptor and modest antagonistic effect on D2-like receptors. Clozapine is known to be superior to other antipsychotics and is effective in 30-50% of patients diagnosed with treatment-resistant schizophrenia. However, its use is restricted mainly due to its side effect of agranulocytosis.","PeriodicalId":55549,"journal":{"name":"African Journal of Psychiatry","volume":"16 4","pages":"236, 238"},"PeriodicalIF":0.0000,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4314/ajpsy.v16i4.30","citationCount":"3","resultStr":"{\"title\":\"Clozapine- induced recurrent and transient parotid gland swelling.\",\"authors\":\"A Vohra\",\"doi\":\"10.4314/ajpsy.v16i4.30\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Clozapine is a novel dibenzodiazepine derivative, atypical antipsychotic which exhibits antagonistic activity on 5HT2, alpha 1, alpha 2, H1 and M1, M2, M3 and M5 receptors; agonist activity at the M4 muscarinic receptor and modest antagonistic effect on D2-like receptors. Clozapine is known to be superior to other antipsychotics and is effective in 30-50% of patients diagnosed with treatment-resistant schizophrenia. However, its use is restricted mainly due to its side effect of agranulocytosis.\",\"PeriodicalId\":55549,\"journal\":{\"name\":\"African Journal of Psychiatry\",\"volume\":\"16 4\",\"pages\":\"236, 238\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.4314/ajpsy.v16i4.30\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"African Journal of Psychiatry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/ajpsy.v16i4.30\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"African Journal of Psychiatry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/ajpsy.v16i4.30","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Clozapine- induced recurrent and transient parotid gland swelling.
Clozapine is a novel dibenzodiazepine derivative, atypical antipsychotic which exhibits antagonistic activity on 5HT2, alpha 1, alpha 2, H1 and M1, M2, M3 and M5 receptors; agonist activity at the M4 muscarinic receptor and modest antagonistic effect on D2-like receptors. Clozapine is known to be superior to other antipsychotics and is effective in 30-50% of patients diagnosed with treatment-resistant schizophrenia. However, its use is restricted mainly due to its side effect of agranulocytosis.
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