胆道癌的新诊断和预后生物标志物。

James R A Skipworth, John F Timms, Stephen P Pereira
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引用次数: 5

摘要

导念:世界范围内胆道癌(BTC,胆管和胆囊肿瘤)的发病率持续上升,唯一可能治愈的治疗方法是手术切除或移植,只有少数患者可能。由于出现较晚和缺乏有效的治疗方法,需要发展早期病变检测技术。涵盖领域:本文综述了目前可用的BTC诊断和预后生物标志物,以及最近发表的描述新的血清、胆汁和尿液生物标志物的研究。专家意见:将新的分析技术,如数字图像分析和荧光原位杂交,纳入现有的管理算法,提高了治疗性内窥镜检查时所采取的刷细胞学检查的准确性。然而,一个关键的目标是发现可靠的、非侵入性的、高灵敏度和特异性的生物标志物。最近在其他癌症中基因测序和表达、克隆进化和肿瘤异质性方面的进展将促进对BTC肿瘤生物学的理解,并促进生物标志物的发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Novel diagnostic and prognostic biomarkers in biliary tract cancer.

Introduction: The worldwide incidence of biliary tract carcinoma (BTC, tumours of the bile ducts and gall-bladder) continues to rise, with the only potentially curative treatment remaining surgical resection or transplantation, possible in only a minority of patients. Late presentation and a paucity of effective treatments mandate the development of techniques for early lesion detection.

Areas covered: This article reviews currently available biomarkers for the diagnosis and prognosis of BTC, as well as recently published studies describing novel serum, bile and urinary biomarkers.

Expert opinion: The incorporation of novel analysis techniques, such as digital image analysis and fluorescence in situ hybridization, into existing management algorithms enhances the accuracy of brush cytology taken at the time of therapeutic endoscopy. However, a key goal is the discovery of reliable non-invasive biomarkers with high sensitivity and specificity. Recent advances in gene sequencing and expression, clonal evolution and tumour heterogeneity in other cancers should advance understanding of BTC tumour biology and facilitate biomarker discovery.

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