皮肤鳞状细胞癌的模拟器:小活检和临床病理相关性的诊断挑战。

IF 1.2 Q3 DERMATOLOGY
Journal of Skin Cancer Pub Date : 2013-01-01 Epub Date: 2013-06-25 DOI:10.1155/2013/752864
Kong-Bing Tan, Sze-Hwa Tan, Derrick Chen-Wee Aw, Huma Jaffar, Thiam-Chye Lim, Shu-Jin Lee, Yoke-Sun Lee
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引用次数: 48

摘要

鳞状细胞癌(SCC)是一种常见且重要的原发性皮肤恶性肿瘤。在皮肤活检中,鳞状细胞癌的特征是明显的鳞状细胞异型性、异常角化和侵袭性特征。偶尔会出现诊断上的困难,特别是在小穿孔活检或表面刮刀活检的情况下,病理学家只能评估部分病变。良性模拟SCC包括假上皮瘤性增生、内分泌鳞状注射器异化症、倒滤泡角化病和角棘瘤,而恶性模拟SCC包括基底细胞癌、黑色素瘤和转移癌。仔细应用历史悠久的诊断标准,密切的临床病理相关性和选择性要求进一步,更深或更广泛的活检仍然是确定正确诊断的最有用的策略。本综述旨在介绍SCC的关键鉴别诊断,讨论常见的诊断缺陷,并推荐处理诊断困难病例的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Simulators of squamous cell carcinoma of the skin: diagnostic challenges on small biopsies and clinicopathological correlation.

Simulators of squamous cell carcinoma of the skin: diagnostic challenges on small biopsies and clinicopathological correlation.

Simulators of squamous cell carcinoma of the skin: diagnostic challenges on small biopsies and clinicopathological correlation.

Simulators of squamous cell carcinoma of the skin: diagnostic challenges on small biopsies and clinicopathological correlation.

Squamous cell carcinoma (SCC) is a common and important primary cutaneous malignancy. On skin biopsies, SCC is characterized by significant squamous cell atypia, abnormal keratinization, and invasive features. Diagnostic challenges may occasionally arise, especially in the setting of small punch biopsies or superficial shave biopsies, where only part of the lesion may be assessable by the pathologist. Benign mimics of SCC include pseudoepitheliomatous hyperplasia, eccrine squamous syringometaplasia, inverted follicular keratosis, and keratoacanthoma, while malignant mimics of SCC include basal cell carcinoma, melanoma, and metastatic carcinoma. The careful application of time-honored diagnostic criteria, close clinicopathological correlation and a selective request for a further, deeper, or wider biopsy remain the most useful strategies to clinch the correct diagnosis. This review aims to present the key differential diagnoses of SCC, to discuss common diagnostic pitfalls, and to recommend ways to deal with diagnostically challenging cases.

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来源期刊
Journal of Skin Cancer
Journal of Skin Cancer DERMATOLOGY-
CiteScore
2.30
自引率
18.20%
发文量
12
审稿时长
21 weeks
期刊介绍: Journal of Skin Cancer is a peer-reviewed, Open Access journal that publishes clinical and translational research on the detection, diagnosis, prevention, and treatment of skin malignancies. The journal encourages the submission of original research articles, review articles, and clinical studies related to pathology, prognostic indicators and biomarkers, novel therapies, as well as drug sensitivity and resistance.
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