致病性，宿主反应和肠出血性大肠杆菌O157:H7感染管理的意义。

IF 2.7 4区医学 Q2 Medicine

Canadian Journal of Gastroenterology Pub Date : 2013-01-01 DOI:10.1155/2013/138673

Nathan K Ho, Aleah C Henry, Kathene Johnson-Henry, Philip M Sherman

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引用次数: 39

摘要

肠出血性大肠杆菌血清型O157:H7是一种通过食物和水传播的病原体，在发展中国家和工业化国家均可引起严重的发病率和死亡率。本文对该病原体的历史、流行病学和演变进行了综述;提供主要毒力因子的机制概述(包括志贺毒素，肠细胞消失致病性岛和pO157质粒);讨论宿主对感染的免疫反应;考虑可用的动物模型;并提供了当前和潜在的未来管理考虑的概述。

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Pathogenicity, host responses and implications for management of enterohemorrhagic Escherichia coli O157:H7 infection.

Enterohemorrhagic Escherichia coli serotype O157:H7 is a food- and waterborne pathogen that causes significant morbidity and mortality in both developing and industrialized nations. The present review focuses on the history, epidemiology and evolution of the pathogen; provides a mechanistic overview of major virulence factors (including Shiga toxins, locus of enterocyte effacement pathogenicity island and pO157 plasmid); discusses host immune responses to infection; considers available animal models; and provides an overview of current and potential future management considerations.

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来源期刊

Canadian Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and liver disease - medicine and surgery. The Canadian Journal of Gastroenterology and Hepatology is sponsored by the Canadian Association of Gastroenterology and the Canadian Association for the Study of the Liver.