阿立哌唑。

Q1 Pharmacology, Toxicology and Pharmaceutics

Profiles of drug substances, excipients, and related methodology Pub Date : 2013-01-01 DOI:10.1016/B978-0-12-407691-4.00002-2

Febry Ardiana, Maria L A D Lestari, Gunawan Indrayanto

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引用次数: 9

摘要

阿立哌唑是一种非典型抗精神病药物，属于苯并恶唑类衍生物。阿立哌唑有多种盐类和多形态。利用x射线衍射、红外光谱、DSC等方法对阿立哌唑的形态进行了鉴别。紫外分光光度法、高效液相色谱法、高效液相色谱法、CE等仪器分析方法均可用于阿立哌唑及其杂质的分析。具有MS/MS检测器的色谱法是分析阿立哌唑及其代谢物的首选方法。阿立哌唑及其制剂的生物利用度研究对优化制剂的剂型具有重要意义。

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Aripiprazole.

Aripiprazole is an atypical antipsychotic drug which belongs to the benzisoxazole derivatives. Aripiprazole is available in many salts and polymorphs forms. X-ray diffraction, IR spectroscopy, and DSC could be used for differentiating the polymorphs of aripiprazole. Some instrumental methods of analysis such as UV spectrophotometer, HPTLC, HPLC, and CE can be applied for analyzing aripiprazole and its impurities. Chromatography methods that have an MS/MS detector is the method of choice for analyzing aripiprazole and its metabolites. Bioavailability studies of the polymorphs of aripiprazole and their pharmaceutical preparations are very important to optimize the formulations of the dosage forms.

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来源期刊

Profiles of drug substances, excipients, and related methodology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

13.10

自引率

0.00%

发文量