{"title":"腹腔注射CART 55-102抑制精神兴奋剂诱导的运动。","authors":"Martin O Job, Michael J Kuhar","doi":"10.4303/jdar/235601","DOIUrl":null,"url":null,"abstract":"<p><p>CART (cocaine and amphetamine regulated transcript) peptide functions as both a neurotransmitter and a hormone and is found both in the central nervous system (CNS) and in the periphery. CART peptide in the nucleus accumbens (NAc) has been implicated in the regulation of cocaine-dopamine-mediated locomotion and self-administration, and amphetamine-mediated locomotion and behavior. However, there are no studies on the effect of systemic administration of CART peptide on cocaine and amphetamine-mediated locomotion. In this study, we tested if the systemic administration of CART 55-102 by the intraperitoneal (ip) route has a functional effect on psychostimulant-mediated locomotion in rats as it does when given into the brain. We determined that ip CART 55-102 attenuates psychostimulant-mediated locomotion as it does when administered into the NAc and display a biphasic dose response curve.</p>","PeriodicalId":37818,"journal":{"name":"Journal of Drug and Alcohol Research","volume":"1 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659824/pdf/nihms423624.pdf","citationCount":"10","resultStr":"{\"title\":\"Intraperitoneal Administration of CART 55-102 Inhibits Psychostimulant-Induced Locomotion.\",\"authors\":\"Martin O Job, Michael J Kuhar\",\"doi\":\"10.4303/jdar/235601\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>CART (cocaine and amphetamine regulated transcript) peptide functions as both a neurotransmitter and a hormone and is found both in the central nervous system (CNS) and in the periphery. CART peptide in the nucleus accumbens (NAc) has been implicated in the regulation of cocaine-dopamine-mediated locomotion and self-administration, and amphetamine-mediated locomotion and behavior. However, there are no studies on the effect of systemic administration of CART peptide on cocaine and amphetamine-mediated locomotion. In this study, we tested if the systemic administration of CART 55-102 by the intraperitoneal (ip) route has a functional effect on psychostimulant-mediated locomotion in rats as it does when given into the brain. We determined that ip CART 55-102 attenuates psychostimulant-mediated locomotion as it does when administered into the NAc and display a biphasic dose response curve.</p>\",\"PeriodicalId\":37818,\"journal\":{\"name\":\"Journal of Drug and Alcohol Research\",\"volume\":\"1 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659824/pdf/nihms423624.pdf\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Drug and Alcohol Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4303/jdar/235601\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Psychology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Drug and Alcohol Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4303/jdar/235601","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Psychology","Score":null,"Total":0}
Intraperitoneal Administration of CART 55-102 Inhibits Psychostimulant-Induced Locomotion.
CART (cocaine and amphetamine regulated transcript) peptide functions as both a neurotransmitter and a hormone and is found both in the central nervous system (CNS) and in the periphery. CART peptide in the nucleus accumbens (NAc) has been implicated in the regulation of cocaine-dopamine-mediated locomotion and self-administration, and amphetamine-mediated locomotion and behavior. However, there are no studies on the effect of systemic administration of CART peptide on cocaine and amphetamine-mediated locomotion. In this study, we tested if the systemic administration of CART 55-102 by the intraperitoneal (ip) route has a functional effect on psychostimulant-mediated locomotion in rats as it does when given into the brain. We determined that ip CART 55-102 attenuates psychostimulant-mediated locomotion as it does when administered into the NAc and display a biphasic dose response curve.
期刊介绍：
The Journal of Drug and Alcohol Research (JDAR) is a scholarly open access, peer-reviewed, and fully refereed journal dedicated to publishing sound papers on advances in the field of drug, opiate, nicotine and alcohol abuse, both basic and clinical. The journal will consider papers from all sub-disciplines and aspects of drug abuse, dependence and addiction research. Manuscripts will be published online as soon as they are accepted, which will reduce the time of publication. Because there are no space limitations or favored topics, all papers, within the scope of the journal, judged to be sound by the reviewers, will be published.
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