stat3在皮肤癌发生中的作用:从相关小鼠模型中获得的见解

IF 1.2 Q3 DERMATOLOGY
Journal of Skin Cancer Pub Date : 2013-01-01 Epub Date: 2013-03-21 DOI:10.1155/2013/684050
Everardo Macias, Dharanija Rao, John Digiovanni
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引用次数: 36

摘要

信号换能器和转录激活因子3 (Stat3)是一种响应细胞因子和生长因子而被激活的细胞质蛋白,是一种转录因子。Stat3在细胞增殖、迁移和存活等多种生物活动中发挥着重要作用。对角化细胞特异性Stat3缺陷小鼠的研究表明,Stat3在皮肤稳态中起重要作用,包括角化细胞迁移、伤口愈合和毛囊生长。构建型和诱导型角质形成细胞特异性Stat3缺失小鼠模型表明,Stat3在多阶段皮肤癌发生的起始和促进阶段都是必需的。在表皮基底层表达Stat3功能突变(Stat3C)的转基因小鼠模型中,进一步的研究揭示了Stat3在皮肤肿瘤进展中的新作用。使用类似的stat3缺失和功能获得小鼠模型的研究表明,stat3在紫外线B (UVB)辐射介导的皮肤癌发生中具有相似的作用。本文综述了利用这些不同的小鼠模型来研究Stat3在皮肤癌变中的作用和潜在机制。鉴于Stat3在皮肤癌发生过程中的重要作用,它是预防和治疗皮肤癌的一个有吸引力的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Role of stat3 in skin carcinogenesis: insights gained from relevant mouse models.

Role of stat3 in skin carcinogenesis: insights gained from relevant mouse models.

Role of stat3 in skin carcinogenesis: insights gained from relevant mouse models.

Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic protein that is activated in response to cytokines and growth factors and acts as a transcription factor. Stat3 plays critical roles in various biological activities including cell proliferation, migration, and survival. Studies using keratinocyte-specific Stat3-deficient mice have revealed that Stat3 plays an important role in skin homeostasis including keratinocyte migration, wound healing, and hair follicle growth. Use of both constitutive and inducible keratinocyte-specific Stat3-deficient mouse models has demonstrated that Stat3 is required for both the initiation and promotion stages of multistage skin carcinogenesis. Further studies using a transgenic mouse model with a gain of function mutant of Stat3 (Stat3C) expressed in the basal layer of the epidermis revealed a novel role for Stat3 in skin tumor progression. Studies using similar Stat3-deficient and gain-of-function mouse models have indicated its similar roles in ultraviolet B (UVB) radiation-mediated skin carcinogenesis. This paper summarizes the use of these various mouse models for studying the role and underlying mechanisms for the function of Stat3 in skin carcinogenesis. Given its significant role throughout the skin carcinogenesis process, Stat3 is an attractive target for skin cancer prevention and treatment.

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来源期刊
Journal of Skin Cancer
Journal of Skin Cancer DERMATOLOGY-
CiteScore
2.30
自引率
18.20%
发文量
12
审稿时长
21 weeks
期刊介绍: Journal of Skin Cancer is a peer-reviewed, Open Access journal that publishes clinical and translational research on the detection, diagnosis, prevention, and treatment of skin malignancies. The journal encourages the submission of original research articles, review articles, and clinical studies related to pathology, prognostic indicators and biomarkers, novel therapies, as well as drug sensitivity and resistance.
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