填补沉默的空白:听力障碍的基因疗法。

Q3 Biochemistry, Genetics and Molecular Biology

Genetics Research International Pub Date : 2012-01-01 Epub Date: 2012-12-04 DOI:10.1155/2012/748698

Joel Sng, Thomas Lufkin

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引用次数: 6

摘要

内耳细胞结构是人体中最复杂、最脆弱的器官之一，容易受到遗传疾病、衰老和环境破坏的影响。由于哺乳动物的耳蜗不能再生感觉毛细胞，毛细胞的丧失是人类耳聋的主要原因。全世界数以百万计的人受到听力障碍(HI)在情感和经济上的破坏性影响。本文就内耳发育与功能调控基因的关键作用作一简要介绍。本文还详细描述了利用对这些分子途径的更好理解的潜在未来治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Filling the silent void: genetic therapies for hearing impairment.

The inner ear cytoarchitecture forms one of the most intricate and delicate organs in the human body and is vulnerable to the effects of genetic disorders, aging, and environmental damage. Owing to the inability of the mammalian cochlea to regenerate sensory hair cells, the loss of hair cells is a leading cause of deafness in humans. Millions of individuals worldwide are affected by the emotionally and financially devastating effects of hearing impairment (HI). This paper provides a brief introduction into the key role of genes regulating inner ear development and function. Potential future therapies that leverage on an improved understanding of these molecular pathways are also described in detail.

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来源期刊

Genetics Research International Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

2.90

自引率

0.00%

发文量

期刊介绍： Genetics Research International is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of genetics and genomics. The journal focuses on articles bearing on heredity, biochemistry, and molecular biology, as well as clinical findings.