{"title":"柚皮素对慢性缩窄性神经性疼痛大鼠异常性痛和痛觉过敏的影响。","authors":"Shyam Kaulaskar, Pravinkumar Bhutada, Anand Rahigude, Dilpesh Jain, Uday Harle","doi":"10.3736/jcim20121223","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To study the analgesic effects of naringenin on chronic constriction injury (CCI) model of neuropathic pain.</p><p><strong>Methods: </strong>After inducing of neuropathic pain by CCI, treatment with 25 and 50 mg/kg of naringenin and 10 mg/kg of pregabalin was given. Rats were evaluated for behavioral tests using Hargreaves apparatus for thermal hyperalgesia, pin prick test for tactile mechanical hyperalgesia and cold water-induced allodynia on days 0, 3, 5, 7, 14 and 21. At the end of study, oxidative stress parameters were measured.</p><p><strong>Results: </strong>Naringenin showed ameliorating action against CCI-induced neuropathic pain in all the tested models. Also, naringenin attenuated the elevated levels of lipid peroxidation and nitric oxide, and restored the level of reduced glutathione.</p><p><strong>Conclusion: </strong>The results of the present investigation suggest that naringenin exhibits analgesic effect in sciatic nerve injury model.</p>","PeriodicalId":23993,"journal":{"name":"Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine","volume":"10 12","pages":"1482-9"},"PeriodicalIF":0.0000,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"34","resultStr":"{\"title\":\"Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain.\",\"authors\":\"Shyam Kaulaskar, Pravinkumar Bhutada, Anand Rahigude, Dilpesh Jain, Uday Harle\",\"doi\":\"10.3736/jcim20121223\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To study the analgesic effects of naringenin on chronic constriction injury (CCI) model of neuropathic pain.</p><p><strong>Methods: </strong>After inducing of neuropathic pain by CCI, treatment with 25 and 50 mg/kg of naringenin and 10 mg/kg of pregabalin was given. Rats were evaluated for behavioral tests using Hargreaves apparatus for thermal hyperalgesia, pin prick test for tactile mechanical hyperalgesia and cold water-induced allodynia on days 0, 3, 5, 7, 14 and 21. At the end of study, oxidative stress parameters were measured.</p><p><strong>Results: </strong>Naringenin showed ameliorating action against CCI-induced neuropathic pain in all the tested models. Also, naringenin attenuated the elevated levels of lipid peroxidation and nitric oxide, and restored the level of reduced glutathione.</p><p><strong>Conclusion: </strong>The results of the present investigation suggest that naringenin exhibits analgesic effect in sciatic nerve injury model.</p>\",\"PeriodicalId\":23993,\"journal\":{\"name\":\"Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine\",\"volume\":\"10 12\",\"pages\":\"1482-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"34\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3736/jcim20121223\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3736/jcim20121223","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain.
Objective: To study the analgesic effects of naringenin on chronic constriction injury (CCI) model of neuropathic pain.
Methods: After inducing of neuropathic pain by CCI, treatment with 25 and 50 mg/kg of naringenin and 10 mg/kg of pregabalin was given. Rats were evaluated for behavioral tests using Hargreaves apparatus for thermal hyperalgesia, pin prick test for tactile mechanical hyperalgesia and cold water-induced allodynia on days 0, 3, 5, 7, 14 and 21. At the end of study, oxidative stress parameters were measured.
Results: Naringenin showed ameliorating action against CCI-induced neuropathic pain in all the tested models. Also, naringenin attenuated the elevated levels of lipid peroxidation and nitric oxide, and restored the level of reduced glutathione.
Conclusion: The results of the present investigation suggest that naringenin exhibits analgesic effect in sciatic nerve injury model.
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