通过晶体学发现药物的早期——个人回忆。

IF 1.8 4区材料科学

Acta Crystallographica Section A Pub Date : 2013-01-01 Epub Date: 2012-12-18 DOI:10.1107/S0108767312050441

Peter M Colman

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引用次数: 2

摘要

劳伦斯·布拉格(Lawrence Bragg)和马克斯·佩鲁茨(Max Perutz)的影响在当代强调药物发现中的“结构使能”方面是显而易见的。值此布拉格方程诞生一百周年之际，人们记住了他在卡文迪什实验室支持最早的生物材料结构研究中的作用。1962年因DNA和蛋白质结构而获得的诺贝尔奖标志着冯·劳厄和布拉格发现的黄金纪念日。

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Early days in drug discovery by crystallography - personal recollections.

The influences of Lawrence Bragg and Max Perutz are evident in the contemporary emphasis on 'structural enablement' in drug discovery. On this occasion of the centenary of Bragg's equation, his role in supporting the earliest structural studies of biological materials at the Cavendish Laboratory is remembered. The 1962 Nobel Prizes for the structures of DNA and proteins marked the golden anniversary of the von Laue and Bragg discoveries.

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来源期刊

Acta Crystallographica Section A 化学-晶体学

自引率

11.10%

发文量

审稿时长

3 months

期刊介绍： Acta Crystallographica Section A: Foundations and Advances publishes articles reporting advances in the theory and practice of all areas of crystallography in the broadest sense. As well as traditional crystallography, this includes nanocrystals, metacrystals, amorphous materials, quasicrystals, synchrotron and XFEL studies, coherent scattering, diffraction imaging, time-resolved studies and the structure of strain and defects in materials. The journal has two parts, a rapid-publication Advances section and the traditional Foundations section. Articles for the Advances section are of particularly high value and impact. They receive expedited treatment and may be highlighted by an accompanying scientific commentary article and a press release. Further details are given in the November 2013 Editorial. The central themes of the journal are, on the one hand, experimental and theoretical studies of the properties and arrangements of atoms, ions and molecules in condensed matter, periodic, quasiperiodic or amorphous, ideal or real, and, on the other, the theoretical and experimental aspects of the various methods to determine these properties and arrangements.