HLA 在脐带血移植中的作用。

Bone Marrow Research Pub Date : 2012-01-01 Epub Date: 2012-10-11 DOI:10.1155/2012/485160
Catherine Stavropoulos-Giokas, Amalia Dinou, Andreas Papassavas
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引用次数: 0

摘要

脐带血是造血干细胞(HSC)的丰富来源,近年来,脐带血已被成功用作治疗各种血液学、免疫学、遗传学和肿瘤学疾病的替代性造血干细胞来源。造血干细胞移植有几个优点,包括移植时间短、减少移植物抗宿主疾病(GVHD)和更好的长期免疫恢复,从而获得相似的长期存活率。研究表明,一定程度的 HLA 不匹配是可以接受的。本综述旨在概述在不同情况下(亲缘、儿科、成人或双单位造血干细胞移植)HLA配型的主要方面、其对移植结果的影响以及 HLA 在供体选择中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of HLA in Cord Blood Transplantation.

In recent years, umbilical cord blood (CB), a rich source of hematopoietic stem cells (HSC), has been used successfully as an alternative HSC source to treat a variety of hematologic, immunologic, genetic, and oncologic disorders. CB has several advantages, including prompt availability of the transplant, decrease of graft versus host disease (GVHD) and better long-term immune recovery, resulting in a similar long-term survival. Studies have shown that some degree of HLA mismatches is acceptable. This review is intended to outline the main aspects of HLA matching in different settings (related, pediatric, adult, or double-unit HSCT), its effect on transplantation outcome and the role of HLA in donor selection.

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