{"title":"2厘米切缘治疗IIA期至IIC期皮肤黑色素瘤的充分性和安全性。","authors":"Michael J Sladden","doi":"10.1001/archdermatol.2012.2682","DOIUrl":null,"url":null,"abstract":"Question:In patients with clinical stage IIA through IIC cutaneous melanoma thicker than 2 mm, is survival different for a 2-cm local excision margin compared with a 4-cm excision margin? Design: Randomized controlled trial. The trial was not masked at any stage. Setting: Multicenter trial in 53 hospitals in 9 European centers in Sweden, Denmark, Estonia, and Norway. Patients: Patients 75 years or younger with primary cutaneous melanoma thicker than 2 mm and with clinicallylocalizeddisease(clinicalstageIIA-C),onthetrunk or upper or lower extremities. Intervention: Wide 2-cm local excision margin compared with a 4-cm excision margin.","PeriodicalId":8175,"journal":{"name":"Archives of dermatology","volume":"148 10","pages":"1197-8"},"PeriodicalIF":0.0000,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1001/archdermatol.2012.2682","citationCount":"0","resultStr":"{\"title\":\"Sufficiency and safety of 2-cm excision margin for stage IIA through stage IIC cutaneous melanoma.\",\"authors\":\"Michael J Sladden\",\"doi\":\"10.1001/archdermatol.2012.2682\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Question:In patients with clinical stage IIA through IIC cutaneous melanoma thicker than 2 mm, is survival different for a 2-cm local excision margin compared with a 4-cm excision margin? Design: Randomized controlled trial. The trial was not masked at any stage. Setting: Multicenter trial in 53 hospitals in 9 European centers in Sweden, Denmark, Estonia, and Norway. Patients: Patients 75 years or younger with primary cutaneous melanoma thicker than 2 mm and with clinicallylocalizeddisease(clinicalstageIIA-C),onthetrunk or upper or lower extremities. Intervention: Wide 2-cm local excision margin compared with a 4-cm excision margin.\",\"PeriodicalId\":8175,\"journal\":{\"name\":\"Archives of dermatology\",\"volume\":\"148 10\",\"pages\":\"1197-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1001/archdermatol.2012.2682\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of dermatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1001/archdermatol.2012.2682\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of dermatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1001/archdermatol.2012.2682","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Sufficiency and safety of 2-cm excision margin for stage IIA through stage IIC cutaneous melanoma.
Question:In patients with clinical stage IIA through IIC cutaneous melanoma thicker than 2 mm, is survival different for a 2-cm local excision margin compared with a 4-cm excision margin? Design: Randomized controlled trial. The trial was not masked at any stage. Setting: Multicenter trial in 53 hospitals in 9 European centers in Sweden, Denmark, Estonia, and Norway. Patients: Patients 75 years or younger with primary cutaneous melanoma thicker than 2 mm and with clinicallylocalizeddisease(clinicalstageIIA-C),onthetrunk or upper or lower extremities. Intervention: Wide 2-cm local excision margin compared with a 4-cm excision margin.
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