调节性T细胞和过敏反应的控制。

Journal of allergy Pub Date : 2012-01-01 Epub Date: 2012-09-29 DOI:10.1155/2012/948901
Ana Agua-Doce, Luis Graca
{"title":"调节性T细胞和过敏反应的控制。","authors":"Ana Agua-Doce,&nbsp;Luis Graca","doi":"10.1155/2012/948901","DOIUrl":null,"url":null,"abstract":"<p><p>The study of immune regulation and tolerance has been traditionally associated with self/nonself-discrimination. However, the finding that dominant tolerance, a model that puts in evidence the active role of regulatory T cells, can develop to nonself-antigens suggests that the imposition of tolerance can be context dependent. This paper reviews the emerging field of acquired immune tolerance to non-self antigens, with an emphasis on the different subsets of induced regulatory T cells that appear to specialize in specific functional niches. Such regulatory mechanisms are important in preventing the onset of allergic diseases in healthy individuals. In addition, it may be possible to take advantage of these immune regulatory mechanisms for the induction of tolerance in cases where pathological immune responses are generated to allergens occurring in nature, but also to other immunogens such as biological drugs developed for medical therapies.</p>","PeriodicalId":88910,"journal":{"name":"Journal of allergy","volume":"2012 ","pages":"948901"},"PeriodicalIF":0.0000,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/948901","citationCount":"13","resultStr":"{\"title\":\"Regulatory T cells and the control of the allergic response.\",\"authors\":\"Ana Agua-Doce,&nbsp;Luis Graca\",\"doi\":\"10.1155/2012/948901\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The study of immune regulation and tolerance has been traditionally associated with self/nonself-discrimination. However, the finding that dominant tolerance, a model that puts in evidence the active role of regulatory T cells, can develop to nonself-antigens suggests that the imposition of tolerance can be context dependent. This paper reviews the emerging field of acquired immune tolerance to non-self antigens, with an emphasis on the different subsets of induced regulatory T cells that appear to specialize in specific functional niches. Such regulatory mechanisms are important in preventing the onset of allergic diseases in healthy individuals. In addition, it may be possible to take advantage of these immune regulatory mechanisms for the induction of tolerance in cases where pathological immune responses are generated to allergens occurring in nature, but also to other immunogens such as biological drugs developed for medical therapies.</p>\",\"PeriodicalId\":88910,\"journal\":{\"name\":\"Journal of allergy\",\"volume\":\"2012 \",\"pages\":\"948901\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/2012/948901\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of allergy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2012/948901\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2012/9/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of allergy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2012/948901","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2012/9/29 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 13

摘要

免疫调节和耐受性的研究传统上与自我/非自我歧视有关。然而,显性耐受性(一种证明调节性T细胞积极作用的模型)可以发展成非自身抗原的发现表明,耐受性的施加可能取决于环境。本文回顾了对非自体抗原获得性免疫耐受的新兴领域,重点介绍了诱导调节性T细胞的不同亚群,这些亚群似乎专门针对特定的功能龛。这种调节机制在预防健康个体发生过敏性疾病方面是重要的。此外,在对自然界中发生的过敏原产生病理性免疫反应的情况下,也可以利用这些免疫调节机制诱导耐受性,但也可以对其他免疫原(如为医学治疗开发的生物药物)产生耐受性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Regulatory T cells and the control of the allergic response.

Regulatory T cells and the control of the allergic response.

The study of immune regulation and tolerance has been traditionally associated with self/nonself-discrimination. However, the finding that dominant tolerance, a model that puts in evidence the active role of regulatory T cells, can develop to nonself-antigens suggests that the imposition of tolerance can be context dependent. This paper reviews the emerging field of acquired immune tolerance to non-self antigens, with an emphasis on the different subsets of induced regulatory T cells that appear to specialize in specific functional niches. Such regulatory mechanisms are important in preventing the onset of allergic diseases in healthy individuals. In addition, it may be possible to take advantage of these immune regulatory mechanisms for the induction of tolerance in cases where pathological immune responses are generated to allergens occurring in nature, but also to other immunogens such as biological drugs developed for medical therapies.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信