[肾上腺素能受体基因多态性与人格特征之间的关系]。

Maki Numajiri, Jun Aoki, Daisuke Nishizawa, Shinya Kasai, Yasukazu Ogai, Kazutaka Ikeda, Kazuhiko Iwahashi
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引用次数: 0

摘要

采用气质性格量表(TCI)对192名日本健康人(男121名,女71名)进行了β -肾上腺素能受体(β - ar)基因多态性(snp)与人格的关系研究。在本研究中,统计分析采用整体和性别分别进行。结果表明,ADRB1基因的SD (self-directedness)与49Ser/Gly (rs1801252)、ADRB1基因的P (persistence)与389Arg/Gly (rs1801253)、ADRB2基因的ST (self-transcendence)与27Gln/Glu (rs1042714)之间存在显著相关。在男性受试者中,ADRB1基因中ST与49Ser/Gly、NS(寻求新奇)、HA(避免伤害)、P与389Arg/Gly、P与64Arg/Trp(rsrs4994)之间存在显著关系。在女性受试者中,SD与ADRB1的49Ser/Gly、C (cooperativeness)与ADRB1的389Arg/Gly也存在显著相关。因此,β - ar基因多态性与TCI的几个亚量表之间存在相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The association between beta-adrenergic receptor gene polymorphisms and personality traits].

The relationship between the polymorphisms (SNPs) of the beta-adrenergic receptor (beta-AR) gene and personality assessed by TCI (Temperament and Character Inventory), was studied among 192 healthy Japanese subjects (121 male subjects and 71 female subjects). In this study, the statistical analyses were performed overall and separately for each sex. As a result, it was shown that there were significant relationships between SD (self-directedness) and 49Ser/Gly (rs1801252) in ADRB1, P (persistence) and 389Arg/Gly (rs1801253) in ADRB1, and ST (self-transcendence) and 27Gln/Glu (rs1042714) in ADRB2 overall. Among the male subjects, there were further significant relationships between ST and 49Ser/Gly in ADRB1, NS (novelty-seeking), HA (harm avoidance) and P and 389Arg/Gly in ADRB1, and P and 64Arg/Trp(rsrs4994) in ADRB3. Among the female subjects, there were also significant relationships between SD and 49Ser/Gly in ADRB1, and C (cooperativeness) and 389Arg/Gly in ADRB1. Thus it was shown that there were correlations between beta-AR gene polymorphisms and several subscales of TCI.

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