寻找平衡:不同剂量补偿策略如何改变组蛋白h4调节转录。

Q3 Biochemistry, Genetics and Molecular Biology

Genetics Research International Pub Date : 2012-01-01 Epub Date: 2011-10-19 DOI:10.1155/2012/795069

Michael B Wells, Györgyi Csankovszki, Laura M Custer

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引用次数: 6

摘要

剂量补偿平衡了性染色体和常染色体之间的基因表达水平以及性染色体相关基因在两性之间的表达水平。不同的剂量补偿策略在不同的谱系中进化，但都涉及染色质的变化。本文讨论了我们目前对组蛋白H4尾部修饰的理解，特别是H4赖氨酸16乙酰化和H4赖氨酸20甲基化水平的变化，如何在不同的背景下用于两倍调节基因表达水平或完全抑制转录。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Finding a balance: how diverse dosage compensation strategies modify histone h4 to regulate transcription.

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Finding a balance: how diverse dosage compensation strategies modify histone h4 to regulate transcription.

Dosage compensation balances gene expression levels between the sex chromosomes and autosomes and sex-chromosome-linked gene expression levels between the sexes. Different dosage compensation strategies evolved in different lineages, but all involve changes in chromatin. This paper discusses our current understanding of how modifications of the histone H4 tail, particularly changes in levels of H4 lysine 16 acetylation and H4 lysine 20 methylation, can be used in different contexts to either modulate gene expression levels twofold or to completely inhibit transcription.

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来源期刊

Genetics Research International Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

2.90

自引率

0.00%

发文量

期刊介绍： Genetics Research International is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of genetics and genomics. The journal focuses on articles bearing on heredity, biochemistry, and molecular biology, as well as clinical findings.