以萘普生为模型药物的丝素基给药平台的设计与表征。

Journal of drug delivery Pub Date : 2012-01-01 Epub Date: 2012-02-27 DOI:10.1155/2012/490514
Tatyana Dyakonov, Chue Hue Yang, Derek Bush, Saujanya Gosangari, Shingai Majuru, Aqeel Fatmi
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引用次数: 66

摘要

本概念验证研究的目的是开发一种基于丝素蛋白(SF)的可控给药平台,并探讨丝素蛋白用于口服给药的可行性。通过喷雾干燥和膜铸法制备了含sf的基质,并对模型药物萘普生钠的释放特性进行了评价。利用衰减全反射傅立叶变换红外光谱(FTIR)观察了含SF和含药物组合物的构象变化。制备了sf基膜、喷雾干燥微颗粒和负载萘普生的基质。FTIR光谱和体外溶出度数据表明,SF β-薄片构象调节萘普生的释放谱。研究了含SF成分的控释特性与SF浓度、温度和暴露于脱水溶剂的关系。结果表明,SF可能是一种有吸引力的聚合物,用于控制药物输送系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Design and characterization of a silk-fibroin-based drug delivery platform using naproxen as a model drug.

Design and characterization of a silk-fibroin-based drug delivery platform using naproxen as a model drug.

Design and characterization of a silk-fibroin-based drug delivery platform using naproxen as a model drug.

Design and characterization of a silk-fibroin-based drug delivery platform using naproxen as a model drug.

The objective of this proof-of-concept study was to develop a platform for controlled drug delivery based on silk fibroin (SF) and to explore the feasibility of using SF in oral drug delivery. The SF-containing matrixes were prepared via spray-drying and film casting, and the release profile of the model drug naproxen sodium was evaluated. Attenuated total reflectance Fourier transform infrared spectroscopy (FTIR) has been used to observe conformational changes in SF- and drug-containing compositions. SF-based films, spray-dried microparticles, and matrixes loaded with naproxen were prepared. Both FTIR spectra and in vitro dissolution data demonstrated that SF β-sheet conformation regulates the release profile of naproxen. The controlled release characteristics of the SF-containing compositions were evaluated as a function of SF concentration, temperature, and exposure to dehydrating solvents. The results suggest that SF may be an attractive polymer for use in controlled drug delivery systems.

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来源期刊
Journal of drug delivery
Journal of drug delivery PHARMACOLOGY & PHARMACY-
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