葡萄糖胺诱导内质网应激在糖尿病动脉粥样硬化中的作用。

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-02-23 DOI:10.1155/2012/187018
Daniel R Beriault, Geoff H Werstuck
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引用次数: 20

摘要

心血管疾病(CVD)是糖尿病患者死亡的主要原因。然而,使糖尿病患者易发生和发展动脉粥样硬化的分子和细胞机制尚不清楚,动脉粥样硬化是大多数心血管疾病的根本原因。本文综述了目前我们对糖尿病和高血糖与动脉粥样硬化发生联系的途径和机制的认识。我们强调了我们实验室和其他人最近的工作,这些工作支持内质网应激在这些过程中的作用。继续研究高血糖和糖尿病与动脉粥样硬化之间的现有途径,并确定新的机制和靶点,对于开发针对糖尿病患者的新的有效的抗动脉粥样硬化治疗方法至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The role of glucosamine-induced ER stress in diabetic atherogenesis.

The role of glucosamine-induced ER stress in diabetic atherogenesis.

The role of glucosamine-induced ER stress in diabetic atherogenesis.

The role of glucosamine-induced ER stress in diabetic atherogenesis.

Cardiovascular disease (CVD) is the major cause of mortality in individuals with diabetes mellitus. However the molecular and cellular mechanisms that predispose individuals with diabetes to the development and progression of atherosclerosis, the underlying cause of most CVD, are not understood. This paper summarizes the current state of our knowledge of pathways and mechanisms that may link diabetes and hyperglycemia to atherogenesis. We highlight recent work from our lab, and others', that supports a role for ER stress in these processes. The continued investigation of existing pathways, linking hyperglycemia and diabetes mellitus to atherosclerosis, and the identification of novel mechanisms and targets will be important to the development of new and effective antiatherosclerotic therapies tailored to individuals with diabetes.

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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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