血清c反应蛋白升高与中年人脑肌醇水平升高有关。

Cardiovascular psychiatry and neurology Pub Date : 2012-01-01 Epub Date: 2012-02-22 DOI:10.1155/2012/120540
Danielle E Eagan, Mitzi M Gonzales, Takashi Tarumi, Hirofumi Tanaka, Sandra Stautberg, Andreana P Haley
{"title":"血清c反应蛋白升高与中年人脑肌醇水平升高有关。","authors":"Danielle E Eagan,&nbsp;Mitzi M Gonzales,&nbsp;Takashi Tarumi,&nbsp;Hirofumi Tanaka,&nbsp;Sandra Stautberg,&nbsp;Andreana P Haley","doi":"10.1155/2012/120540","DOIUrl":null,"url":null,"abstract":"<p><p>C-reactive protein (CRP), a systemic marker of inflammation, is a risk factor for late life cognitive impairment and dementia, yet the mechanisms that link elevated CRP to cognitive decline are not fully understood. In this study we examined the relationship between CRP and markers of neuronal integrity and cerebral metabolism in middle-aged adults with intact cognitive function, using proton magnetic resonance spectrocospy. We hypothesized that increased levels of circulating CRP would correlate with changes in brain metabolites indicative of early brain vulnerability. Thirty-six individuals, aged 40 to 60, underwent neuropsychological assessment, a blood draw for CRP quantification, and (1)H MRS examining N-acetyl-aspartate, myo-inositol, creatine, choline, and glutamate concentrations in occipito-parietal grey matter. Independent of age, sex and education, serum CRP was significantly related to higher cerebral myo-inositol/creatine ratio (F(4,31) = 4.74, P = 0.004), a relationship which remained unchanged after adjustment for cardiovascular risk (F(5,30) = 4.356, CRP β = 0.322, P = 0.045). Because these biomarkers are detectable in midlife they may serve as useful indicators of brain vulnerability during the preclinical period when mitigating intervention is still possible.</p>","PeriodicalId":88441,"journal":{"name":"Cardiovascular psychiatry and neurology","volume":"2012 ","pages":"120540"},"PeriodicalIF":0.0000,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/120540","citationCount":"41","resultStr":"{\"title\":\"Elevated serum C-reactive protein relates to increased cerebral myoinositol levels in middle-aged adults.\",\"authors\":\"Danielle E Eagan,&nbsp;Mitzi M Gonzales,&nbsp;Takashi Tarumi,&nbsp;Hirofumi Tanaka,&nbsp;Sandra Stautberg,&nbsp;Andreana P Haley\",\"doi\":\"10.1155/2012/120540\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>C-reactive protein (CRP), a systemic marker of inflammation, is a risk factor for late life cognitive impairment and dementia, yet the mechanisms that link elevated CRP to cognitive decline are not fully understood. In this study we examined the relationship between CRP and markers of neuronal integrity and cerebral metabolism in middle-aged adults with intact cognitive function, using proton magnetic resonance spectrocospy. We hypothesized that increased levels of circulating CRP would correlate with changes in brain metabolites indicative of early brain vulnerability. Thirty-six individuals, aged 40 to 60, underwent neuropsychological assessment, a blood draw for CRP quantification, and (1)H MRS examining N-acetyl-aspartate, myo-inositol, creatine, choline, and glutamate concentrations in occipito-parietal grey matter. Independent of age, sex and education, serum CRP was significantly related to higher cerebral myo-inositol/creatine ratio (F(4,31) = 4.74, P = 0.004), a relationship which remained unchanged after adjustment for cardiovascular risk (F(5,30) = 4.356, CRP β = 0.322, P = 0.045). Because these biomarkers are detectable in midlife they may serve as useful indicators of brain vulnerability during the preclinical period when mitigating intervention is still possible.</p>\",\"PeriodicalId\":88441,\"journal\":{\"name\":\"Cardiovascular psychiatry and neurology\",\"volume\":\"2012 \",\"pages\":\"120540\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/2012/120540\",\"citationCount\":\"41\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cardiovascular psychiatry and neurology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2012/120540\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2012/2/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiovascular psychiatry and neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2012/120540","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2012/2/22 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 41

摘要

c反应蛋白(CRP)是一种全身炎症标志物,是晚年认知障碍和痴呆的危险因素,但CRP升高与认知能力下降之间的机制尚不完全清楚。在这项研究中,我们使用质子磁共振波谱检查了CRP与认知功能完好的中年人神经元完整性和脑代谢标志物之间的关系。我们假设循环CRP水平的升高与表明早期大脑易损性的脑代谢物变化有关。36名年龄在40至60岁之间的个体接受了神经心理学评估,抽血进行CRP定量,(1)hmrs检查枕顶叶灰质中n -乙酰-天冬氨酸、肌醇、肌酸、胆碱和谷氨酸的浓度。血清CRP与较高的脑肌醇/肌酸比值有显著相关性(F(4,31) = 4.74, P = 0.004),不受年龄、性别和教育程度的影响,在调整心血管风险后,这一关系保持不变(F(5,30) = 4.356, CRP β = 0.322, P = 0.045)。由于这些生物标志物在中年时可检测到,因此它们可能在临床前阶段作为大脑易损性的有用指标,此时减轻干预仍然是可能的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Elevated serum C-reactive protein relates to increased cerebral myoinositol levels in middle-aged adults.

Elevated serum C-reactive protein relates to increased cerebral myoinositol levels in middle-aged adults.

C-reactive protein (CRP), a systemic marker of inflammation, is a risk factor for late life cognitive impairment and dementia, yet the mechanisms that link elevated CRP to cognitive decline are not fully understood. In this study we examined the relationship between CRP and markers of neuronal integrity and cerebral metabolism in middle-aged adults with intact cognitive function, using proton magnetic resonance spectrocospy. We hypothesized that increased levels of circulating CRP would correlate with changes in brain metabolites indicative of early brain vulnerability. Thirty-six individuals, aged 40 to 60, underwent neuropsychological assessment, a blood draw for CRP quantification, and (1)H MRS examining N-acetyl-aspartate, myo-inositol, creatine, choline, and glutamate concentrations in occipito-parietal grey matter. Independent of age, sex and education, serum CRP was significantly related to higher cerebral myo-inositol/creatine ratio (F(4,31) = 4.74, P = 0.004), a relationship which remained unchanged after adjustment for cardiovascular risk (F(5,30) = 4.356, CRP β = 0.322, P = 0.045). Because these biomarkers are detectable in midlife they may serve as useful indicators of brain vulnerability during the preclinical period when mitigating intervention is still possible.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信