{"title":"用锝-99m标记单宁酸诊断胃溃疡。","authors":"I T Ibrahim, M El-Tawoosy, H M Talaat","doi":"10.5402/2011/578570","DOIUrl":null,"url":null,"abstract":"<p><p>Tannic acid is a polyphenolic compound that could be labeled with technetium-99m. To produce about 90% yield of (99m)Tc-tannic acid in acidic media (pH), the conditions required were 150 μg tin chloride, 30 min reaction time, and 200 μg of the substrate. (99m)Tc-tannic was stable for 6 h. Oral biodistribution of (99m)Tc-tannic showed that it concentrated in the stomach ulcer to reach about 50% of the total injected dose at 1 h after orall administration. This concentration of (99m)Tc-tannic in stomach ulcer may be sufficient to radio-image the presence of ulcer in the stomach.</p>","PeriodicalId":14802,"journal":{"name":"ISRN Pharmaceutics","volume":"2011 ","pages":"578570"},"PeriodicalIF":0.0000,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/578570","citationCount":"0","resultStr":"{\"title\":\"Labeling of tannic Acid with technetium-99m for diagnosis of stomach ulcer.\",\"authors\":\"I T Ibrahim, M El-Tawoosy, H M Talaat\",\"doi\":\"10.5402/2011/578570\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Tannic acid is a polyphenolic compound that could be labeled with technetium-99m. To produce about 90% yield of (99m)Tc-tannic acid in acidic media (pH), the conditions required were 150 μg tin chloride, 30 min reaction time, and 200 μg of the substrate. (99m)Tc-tannic was stable for 6 h. Oral biodistribution of (99m)Tc-tannic showed that it concentrated in the stomach ulcer to reach about 50% of the total injected dose at 1 h after orall administration. This concentration of (99m)Tc-tannic in stomach ulcer may be sufficient to radio-image the presence of ulcer in the stomach.</p>\",\"PeriodicalId\":14802,\"journal\":{\"name\":\"ISRN Pharmaceutics\",\"volume\":\"2011 \",\"pages\":\"578570\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.5402/2011/578570\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ISRN Pharmaceutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5402/2011/578570\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2011/7/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ISRN Pharmaceutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5402/2011/578570","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2011/7/19 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Labeling of tannic Acid with technetium-99m for diagnosis of stomach ulcer.
Tannic acid is a polyphenolic compound that could be labeled with technetium-99m. To produce about 90% yield of (99m)Tc-tannic acid in acidic media (pH), the conditions required were 150 μg tin chloride, 30 min reaction time, and 200 μg of the substrate. (99m)Tc-tannic was stable for 6 h. Oral biodistribution of (99m)Tc-tannic showed that it concentrated in the stomach ulcer to reach about 50% of the total injected dose at 1 h after orall administration. This concentration of (99m)Tc-tannic in stomach ulcer may be sufficient to radio-image the presence of ulcer in the stomach.
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