Manuela Donati, Antonietta Di Francesco, Maria Di Paolo, Natascia Fiani, Monica Benincasa, Renato Gennaro, Paola Nardini, Claudio Foschi, Roberto Cevenini
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Activity of Cathelicidin Peptides against Simkania negevensis.
The in vitro activity of six cathelicidin peptides against the reference strain Z of Simkania negevensis was investigated. Five peptides-PG-1, Bac7, SMAP-29, BMAP-27, and BMAP-28-proved to be active at very low concentrations (1 to 0.1 μg/mL), while LL-37 cathelicidin was ineffective even at a concentration of 100 μg/mL. In comparison to chlamydiae, S. negevensis proved to be more susceptible to the antimicrobial peptides tested.
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