超临界流体法制备西罗莫司脂质体及其影响因素。

Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2012-02-01 Epub Date: 2011-06-21 DOI:10.3109/10731199.2011.585618

Wei Zhang, Yong Sun, Yongjian Li, Ruowu Shen, Hongli Ni, Dejian Hu

{"title":"超临界流体法制备西罗莫司脂质体及其影响因素。","authors":"Wei Zhang, Yong Sun, Yongjian Li, Ruowu Shen, Hongli Ni, Dejian Hu","doi":"10.3109/10731199.2011.585618","DOIUrl":null,"url":null,"abstract":"We prepared the sirolimus liposome by rapid expansion of supercritical solution (RESS) technology of supercritical fluid, and studied the effects of temperature, pressure, and equilibrium time on the average particle size and envelop rate of liposome. The conditions of the minimal average particle size of liposome were 328K of temperature (35MPa), 35MPa of pressure (333K), and 50 minutes of equilibrium (343K) time, respectively. The conditions of the maximal envelop rate of liposome were 333K of temperature (30MPa), 35MPa of pressure (343K), and 50 minutes of equilibrium (323K) time, respectively.","PeriodicalId":8413,"journal":{"name":"Artificial cells, blood substitutes, and immobilization biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199.2011.585618","citationCount":"23","resultStr":"{\"title\":\"Preparation and influencing factors of sirolimus liposome by supercritical fluid.\",\"authors\":\"Wei Zhang, Yong Sun, Yongjian Li, Ruowu Shen, Hongli Ni, Dejian Hu\",\"doi\":\"10.3109/10731199.2011.585618\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We prepared the sirolimus liposome by rapid expansion of supercritical solution (RESS) technology of supercritical fluid, and studied the effects of temperature, pressure, and equilibrium time on the average particle size and envelop rate of liposome. The conditions of the minimal average particle size of liposome were 328K of temperature (35MPa), 35MPa of pressure (333K), and 50 minutes of equilibrium (343K) time, respectively. The conditions of the maximal envelop rate of liposome were 333K of temperature (30MPa), 35MPa of pressure (343K), and 50 minutes of equilibrium (323K) time, respectively.\",\"PeriodicalId\":8413,\"journal\":{\"name\":\"Artificial cells, blood substitutes, and immobilization biotechnology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/10731199.2011.585618\",\"citationCount\":\"23\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Artificial cells, blood substitutes, and immobilization biotechnology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3109/10731199.2011.585618\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2011/6/21 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Artificial cells, blood substitutes, and immobilization biotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/10731199.2011.585618","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2011/6/21 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 23

摘要

采用超临界流体快速膨胀技术制备了西罗莫司脂质体，研究了温度、压力和平衡时间对脂质体平均粒径和包膜速率的影响。脂质体的最小平均粒径条件分别为温度328K (35MPa)、压力35MPa (333K)和平衡时间50min (343K)。脂质体的最大包膜率条件分别为温度333K (30MPa)、压力35MPa (343K)和平衡时间50min (323K)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Preparation and influencing factors of sirolimus liposome by supercritical fluid.

We prepared the sirolimus liposome by rapid expansion of supercritical solution (RESS) technology of supercritical fluid, and studied the effects of temperature, pressure, and equilibrium time on the average particle size and envelop rate of liposome. The conditions of the minimal average particle size of liposome were 328K of temperature (35MPa), 35MPa of pressure (333K), and 50 minutes of equilibrium (343K) time, respectively. The conditions of the maximal envelop rate of liposome were 333K of temperature (30MPa), 35MPa of pressure (343K), and 50 minutes of equilibrium (323K) time, respectively.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Artificial cells, blood substitutes, and immobilization biotechnology 工程技术-材料科学：生物材料

自引率

0.00%

发文量

审稿时长

6-12 weeks